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Debate 23B - What is the Best Management Option for Malignant Bowel Obstruction?

Percutaneous Endoscopic Gastrostomy

from Section III - Ovarian Cancer

Published online by Cambridge University Press:  20 July 2023

Dennis S. Chi
Affiliation:
Memorial Sloan-Kettering Cancer Center, New York
Nisha Lakhi
Affiliation:
Richmond University Medical Center, Staten Island
Nicoletta Colombo
Affiliation:
University of Milan-Bicocca
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Summary

Malignant bowel obstruction is one of the toughest clinical challenges in gynecology. Few rigorous clinical trials exist to guide management.While conservative options should be exhausted first, palliative bowel surgery remains the only approach offering the possibility of quality time, restoration of oral nutrition, and on-going cancer-directed therapy. The capacity to address malignant bowel obstruction becomes ever more critical as many of the most promising new treatments for gynecologic malignancy are targeted biologic oral agents. The best candidates for surgery are obstructed in a single location, naive to prior bowel obstruction surgery, have treatment options remaining, and have minimal ascites or carcinomatosis. Postoperative 30-day mortality after palliative bowel surgery ranges from 4–40% and perioperative morbidity including postoperative pain, bowel leaks, abscess, sepsis are high, range from 5–86%.Thus, the choice to proceed with surgery requires exceptional doctor–patient communication, a highly skilled surgical team, and meticulous patient selection.

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Publisher: Cambridge University Press
Print publication year: 2023

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References

Lee, YC, et al. Optimizing care of malignant bowel obstruction in patients with advanced gynecologic cancer. J Oncol Pract 2019;15(12):e10661071.CrossRefGoogle ScholarPubMed
Lilley, EJ, et al. Survival, healthcare utilization and end-of-life care in older adults with malignancy-associated malignant bowel obstruction; comparative study of surgery, venting gastrostomy, or medical management. Ann Surg 2018;267(4):692699.CrossRefGoogle ScholarPubMed
Hoppenot, C, et al. Malignant bowel obstruction due to ovarian or uterine cancer: are there differences in outcome? Gynecol Oncol 2019;154(1):177182.CrossRefGoogle ScholarPubMed
Cusimano, MC, et al. Supported self-management as a model for end-of-life care in the setting of malignant bowel obstruction: a qualitative study. Gynecol Oncol 2020;157(3):745753.CrossRefGoogle Scholar
Zucchi, E, et al. Decompressive percutaneous endoscopic gastrostomy in advanced cancer patients with small-bowel obstruction is feasible and effective: a large prospective study. Support Care Cancer 2016;24:28772882.Google ScholarPubMed

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