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Chemotherapy
from Section III - Ovarian Cancer
Published online by Cambridge University Press: 20 July 2023
Patients with early-stage granulosa cell tumors (IA or IB) may be treated with surgical therapy alone and expect an excellent prognosis. Patients with stage IC or greater disease, recurrent granulosa cell tumors, and sub-optimally reduced disease may benefit from adjuvant chemotherapy. The type of adjuvant chemotherapy has been controversial and varies based on clinical guidelines. The National Comprehensive Cancer Network (NCCN) guidelines recommend platinum-based chemotherapy and endorses paclitaxel and carboplatin (PC), etoposide and cisplatin, or bleomycin, etoposide, cisplatin (BEP). In this debate the following article, we prefer the authors support the use of paclitaxel plus carboplatin based on (1) BEP lacks durable activity, (2) PC demonstrates favorable outcomes in a retrospective analysis, (3) PC has a better safety profile compared to BEP, (4) the dosing regimen for PC is more convenient, and (5) there is insufficient data comparing PC to BEP.
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