Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-28T04:55:16.805Z Has data issue: false hasContentIssue false

41A - AMH Is a Better Predictor of Ovarian Response Than AFC

For

from Section VIII - Ovarian Stimulation

Published online by Cambridge University Press:  25 November 2021

By
Antonio La Marca  and
Valentina Grisendi
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
Get access

Summary

In medically assisted reproduction, markers of ovarian reserve are largely used as predictors of ovarian response with the aim to individualise ovarian stimulation therapy and to counsel patients on reproductive outcome. For several years, serum AMH and ultrasound antral follicle count (AFC) have shown to be the most accurate markers and to be highly correlated. The demonstration of AMH’s major predictive value in one trial and two trials post-hoc analyses lays a first solid foundation for the supremacy of this marker. Other studies are needed, but we think that AMH dosing with new automated assays could only confirm these results.

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 210 - 211
Publisher: Cambridge University Press
Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

van Rooij, IA, Broekmans, FJ, te Velde, ER, et al. Serum anti-Müllerian hormone levels: a novel measure of ovarian reserve. Hum Reprod. 2002;17(12):3065–71.CrossRefGoogle Scholar
Broer, SL, van Disseldorp, J, Broeze, KA, et al. Added value of ovarian reserve testing on patient characteristics in the prediction of ovarian response and ongoing pregnancy: an individual patient data approach. Hum Reprod Update. 2013;19(1):26–36.CrossRefGoogle ScholarPubMed
Broer, SL, Dólleman, M, van Disseldorp, J, et al. Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis. Fertil Steril. 2013;100(2):420–9.e7.CrossRefGoogle ScholarPubMed
Anderson, RA, Anckaert, E, Bosch, E, et al. Prospective study into the value of the automated elecsys antimüllerian hormone assay for the assessment of the ovarian growing follicle pool. Fertil Steril. 2015;103(4):1074–80.e4.CrossRefGoogle ScholarPubMed
Nelson, SM, Klein, BM, Arce, JC. Comparison of antimüllerian hormone levels and antral follicle count as predictor of ovarian response to controlled ovarian stimulation in good-prognosis patients at individual fertility clinics in two multicenter trials. Fertil Steril. 2015;103(4):923–30.e1.CrossRefGoogle ScholarPubMed
Andersen, AN, Witjes, H, Gordon, K, Mannaerts, B. Predictive factors of ovarian response and clinical outcome after IVF/ICSI following a rFSH/GnRH antagonist protocol with or without oral contraceptive pre-treatment. Hum Reprod. 2011;26:3413–23.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×