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22B - Intramural Fibroids Greater than 4 cm in Diameter Should Be Removed to Aid Fertility

Against

from Section III - The Best Policy

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

The evidence regarding intramural fibroids and fertility treatment outcomes is highly controversial and the evidence is significantly compromised by heterogeneity caused by a lack of clear definition of the size and number of intramural fibroids and their proximity to the endometrium as well as the presence of other types of fibroids and individual confounding variables. Furthermore, there is a lack of evidence that surgical removal of intramural fibroids would benefit fertility treatment. Until definitive evidence is available, surgical removal of intramural fibroids of 4cm or more is unjustified.

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Pritts, EA, Parker, WH, Olive, DL. Fibroids and infertility: an updated systematic review of the evidence. Fertil Steril. 2009;91:1215–23.CrossRefGoogle ScholarPubMed
Sunkara, SK, Khairy, M, El-Toukhy, T, Khalaf, Y, Coomarasamy, A. The effect of intramural fibroids without uterine cavity involvement on the outcome of IVF treatment: a systematic review and meta-analysis. Hum Reprod. 2010;25:418–29.CrossRefGoogle ScholarPubMed
Donnez, J, Jadoul, P. What are the implications of myomas on fertility? A need for a debate?Hum Reprod. 2002;17:1424–30.CrossRefGoogle ScholarPubMed
Metwally, M, Farquhar, CM, Li, TC. Is another meta-analysis on the effects of intramural fibroids on reproductive outcomes needed? Reprod Biomed. 2011;23:214.CrossRefGoogle ScholarPubMed
Wang, X, Chen, L, Wang, H, Li, Q, Liu, X, Qi, H. The impact of noncavity-distorting intramural fibroids on the efficacy of in vitro fertilization-embryo transfer: an updated meta-analysis. Biomed Res Int. 2018;2018:8924703.Google ScholarPubMed

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