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17A - Luteal-Phase Support Should Be Stopped at the Time of a Positive Pregnancy Test

For

from Section III - The Best Policy

Published online by Cambridge University Press:  25 November 2021

By
Juan A Garcia-Velasco
Edited by
Roy Homburg ,
Adam H. Balen  and
Robert F. Casper
Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

Of the many empirical interventions that we routinely do in ART, luteal phase support is one of the most controversial. Although the placenta takes over the corpus luteum function very early in the pregnancy, there is a trend to maintain luteal phase support in fresh IVF cycles beyond the luteo-placental shift and extended till week 10-12. Several RCTs and meta-analyses demonstrate with robust data that postponing luteal phase support beyond week 5/6 does not improve live birth rate, so not only is it not required but we could be unnecessarily over treating our patients.

Type
Chapter
Information
50 Big Debates in Reproductive Medicine , pp. 90 - 92
Publisher: Cambridge University Press
Print publication year: 2021

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References

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Liu, X, Mu, H, Shi, Q, et al. The optimal duration of progesterone supplementation in pregnant women after IVF/ICSI: a meta-analysis. Reprod Biol Endocrinol. 2012;10:107.CrossRefGoogle ScholarPubMed

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