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45A - Metformin Is an Effective Treatment for Infertility Associated with Anovulatory PCOS

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from Section IX - Hormones and the Environment

Published online by Cambridge University Press:  25 November 2021

Roy Homburg
Affiliation:
Homerton University Hospital, London
Adam H. Balen
Affiliation:
Leeds Centre for Reproductive Medicine
Robert F. Casper
Affiliation:
Mount Sinai Hospital, Toronto
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Summary

The present chapter will discuss on the potential uses of metformin in the treatment of infertility associated with anovulatory patients with polycystic ovary syndrome (PCOS) using data from randomised controlled trials and systematic reviews with meta-analysis.

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Sharpe, A, Morley, LC, Tang, T, Norman, RJ, Balen, AH. Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome. Cochrane Database Syst Rev. 2019;12:CD013505.Google ScholarPubMed
Wang, R, Li, W, Bordewijk, EM, et al. Reproductive Medicine Network; International Ovulation Induction IPDMA Collaboration. First-line ovulation induction for polycystic ovary syndrome: an individual participant data meta-analysis. Hum Reprod Update. 2019;25(6):717–32.CrossRefGoogle ScholarPubMed
Liu, C, Feng, G, Huang, W, et al. Comparison of clomiphene citrate and letrozole for ovulation induction in women with polycystic ovary syndrome: a prospective randomized trial. Gynecol Endocrinol. 2017;33(11):872–6.CrossRefGoogle ScholarPubMed
Rezk, M, Shaheen, AE, Saif El-Nasr, I. Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene-resistant polycystic ovary syndrome: a randomized clinical trial. Gynecol. Endocrinol. 2018;34(4):298300.CrossRefGoogle ScholarPubMed
Palomba, S, Falbo, A, La Sala, GB. Metformin and gonadotropins for ovulation induction in patients with polycystic ovary syndrome: a systematic review with meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. 2014;12:3.CrossRefGoogle ScholarPubMed

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