Published online by Cambridge University Press: 07 October 2023
The circadian timing system has pronounced effects on learning and memory, with learning and recall regulated by time of day and the cellular mechanisms underlying learning and memory being under circadian control. Given this influence of the circadian system, studies across species, including humans, reveal that circadian disruption has pronounced negative effects on cognitive functioning. Circadian disruption leads to deficits in learning and memory by negatively affecting neurogenesis, synaptic plasticity, and epigenetic events required for acquisition and recall of memories. The present chapter describes the impact of circadian disruption on learning and memory while considering the mechanisms underlying circadian control of cognitive function. Given that the modern world is rife with temporal disruptions due to work requirements, limited exposure to sunlight during the day, and exposure to artificial lighting and blue light-emitting electronic devices at night, understanding the negative impact of circadian disruption on learning and memory and developing mitigating strategies are vital.
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