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Chapter 7 - Pharmacology of Local Anesthetics

Published online by Cambridge University Press:  24 May 2023

By
Chang H. Park  and
Garrett W. Burnett
Edited by
Alan David Kaye  and
Richard D. Urman
Alan David Kaye
Affiliation:
Louisiana State University School of Medicine
Richard D. Urman
Affiliation:
Brigham and Women’s Hospital, Boston
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Summary

Cocaine, derived from the coca leaf indigenous to South America, was the first drug to be utilized as a topical local anesthetic by Dr. Carl Koller for glaucoma surgery in 1884. Dr. William Stewart Halstead and Dr. Richard John Hall were the first to demonstrate nerve blockade with cocaine for dental surgery later in that same year. Due to the undesirable effects of cocaine, novocaine and subsequent other local anesthetics were developed.

Type
Chapter
Information
Cambridge Handbook of Anesthesiology , pp. 106 - 118
Publisher: Cambridge University Press
Print publication year: 2023

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References

Further Reading

Clatayud, J, Gonzalez, A. History of the development and evolution of local anesthesia since the coca leaf. Anesthesiology. 2003;98(6):1503–8.Google Scholar
Taylor, A, McLeod, G. Basic pharmacology of local anaesthetics. BJA Educ. 2020;20(4):34–41.CrossRefGoogle ScholarPubMed

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