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  1. Home
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  3. Cerebral Microbleeds
  • Cited by 31
Publisher:
Cambridge University Press
Online publication date:
July 2011
Print publication year:
2011
Online ISBN:
9780511974892
DOI:
https://doi.org/10.1017/CBO9780511974892
Subjects:
Medical Imaging, Neurology and Clinical Neuroscience, Medicine
Information

Book description

Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.

Reviews

'Cerebral Microbleeds: Pathophysiology to Clinical Practice is a 198-page textbook that covers the entire current state of knowledge on microbleeds, ranging from the historical perspective to current imaging methods and histopathology … David Werring has succeeded in assembling virtually all authorities on cerebral microbleeds to share their knowledge and views on this emerging topic. This has yielded a comprehensive overview that is of interest both to the uninitiated student wanting to know what all the fuss is about and to the more experienced neuroscientist working in the field of cerebral small vessel disease.'

Source: The Lancet

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Contents

Page 2 of 2

Contents
  • Chapter 20 - Cerebral microbleeds and thrombolysis
    pp 173-177
  • View abstract

    Summary

    Cerebral amyloid angiopathy (CAA) occurs commonly in the elderly population. It results in thickening of the vessel wall, primarily in small arteries and arterioles of the leptomeninges and cerebral cortex. Primary intracerebral hemorrhage (ICH) in the elderly is the result of disease of the small cerebral vessels, in particular hypertensive vasculopathy or CAA. The CAA-related cerebral microbleeds (CMBs), like other types of microbleed, consist primarily of macrophages containing hemosiderin, a degraded form of ferritin. The most commonly employed criteria for diagnosis of CAA-related ICH are based on neuropathological examination or, more commonly, characteristic neuroimaging findings. Despite its high age-related prevalence, CAA has been difficult to detect non-invasively and is, likely to be underestimated in its effects on the aging process. The occurrence of CAA-related CMBs has emerged as the most useful diagnostic marker for CAA in clinical practice and investigation.

Page 2 of 2

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