Cholinesterase Inhibitors and Memantine
Published online by Cambridge University Press: 31 October 2024
Alzheimer’s disease is the most common form of major neurocognitive disorder, causing gradual declines in many areas of cognition. Alzheimer’s disease accounts for 60-70% of cases of dementia worldwide. Donepezil is the prototypical cholinesterase inhibitor and was approved for use in 1996. It is FDA approved for the treatment of mild, moderate, or severe Alzheimer’s disease and is considered a symptomatic treatment for Alzheimer’s disease and some other dementias as it does little to alter the course of the disease. The advantages to maintaining patients on cholinesterase inhibitors include continued slowing of the decline in cognition, delaying need for a higher level of care, and potentially delaying the need for medications to address neuropsychiatric symptoms.
To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.