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Chapter 17 - Animal models for cognitive deficits induced by sleep deprivation

from Section 3 - Sleepphysiology and homeostasis

Published online by Cambridge University Press:  05 November 2013

By
Laurent Seugnet  and
Paul Salin
Edited by
Paul Shaw ,
Mehdi Tafti  and
Michael J. Thorpy
Paul Shaw
Affiliation:
University of Washington, St Louis
Mehdi Tafti
Affiliation:
University of Lausanne
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Albert Einstein College of Medicine, New York
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Summary

This chapter provides a brief description of the main animal models used in the study of sleep and cognition, which reveals their intercomplementary strength and scope. Two types of sleep deprivation are commonly carried out in rodents: total sleep deprivation (TSD) and rapid eye movement (REM) sleep deprivation (RSD). Memory consolidation during sleep could be a passive and unselective process due to a prolonged quiet period without any flow of information. The study of sleep-dependent cognitive processes is relatively recent in birds and few studies have so far included sleep deprivation. Sleep deprivation protocols include gentle handling, placing birds in a running wheel, the disc-over-water method, and constant light. Drosophila serves as a model system for the investigation of many cellular, developmental, and behavioral processes common to other species, including humans.

Keywords

norepinephrineoptogeneticsarousal systemshypocretinslocus coeruleus
Type
Chapter
Information
The Genetic Basis of Sleep and Sleep Disorders , pp. 171 - 188
Publisher: Cambridge University Press
Print publication year: 2013

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