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Chapter 10 - In search of estrogen alternatives for the brain

from Section 2 - Varieties of estrogenic therapy

Published online by Cambridge University Press:  06 July 2010

By
Liqin Zhao  and
Roberta Diaz Brinton
Edited by
Eef Hogervorst ,
Victor W. Henderson ,
Robert B. Gibbs  and
Roberta Diaz Brinton
Eef Hogervorst
Affiliation:
Loughborough University
Victor W. Henderson
Affiliation:
Stanford University, California
Robert B. Gibbs
Affiliation:
University of Pittsburgh
Roberta Diaz Brinton
Affiliation:
University of Southern California
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Summary

Editors' introduction

This chapter briefly reviews recent advancements in the search for a non-feminizing estrogen alternative that can mimic estrogen's positive effects on cognitive health without eliciting an undesirable impact on reproductive and cardiovascular systems. The discussion focuses on two avenues of translational development, tissue-selective and subtype-selective estrogen receptor (ER) modulators (SERMs), in particular ERβ-selective phytoSERMs as a natural approach for potentially promoting neurological health and preventing age-associated cognitive impairment and risk of Alzheimer's disease in both genders.

Type
Chapter
Information
Hormones, Cognition and Dementia
State of the Art and Emergent Therapeutic Strategies
 , pp. 93 - 100
Publisher: Cambridge University Press
Print publication year: 2009

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