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Section 5 - Testosterone, estradiol and men, and sex hormone binding globulin

Published online by Cambridge University Press:  06 July 2010

Edited by
Eef Hogervorst ,
Victor W. Henderson ,
Robert B. Gibbs  and
Roberta Diaz Brinton
Eef Hogervorst
Affiliation:
Loughborough University
Victor W. Henderson
Affiliation:
Stanford University, California
Robert B. Gibbs
Affiliation:
University of Pittsburgh
Roberta Diaz Brinton
Affiliation:
University of Southern California
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Summary

Editors' introduction

The extent to which testosterone and other androgens might affect cognitive skills in women is not yet well understood. In this chapter, Sherwin reviews changes in endogenous androgens over a woman's lifespan and research findings germane to androgens and cognitive skills in women. For younger women, there is evidence that cyclical changes during the menstrual cycle affect cognitive performance, although it is not possible to tease out effects of testosterone from those of estradiol. In older women, the relation between testosterone levels and cognitive test scores is inconsistent. The ratio of estradiol to testosterone may be important in modulating sex-advantaged cognitive functions in women, with a lower ratio leading to relatively impaired performance on cognitive tasks in which women typically excel.

Type
Chapter
Information
Hormones, Cognition and Dementia
State of the Art and Emergent Therapeutic Strategies
 , pp. 179 - 250
Publisher: Cambridge University Press
Print publication year: 2009

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