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3.7.10 - Antibiotic Prophylaxis, Resistance and Future Directions

from Section 3.7 - Infection and Immunity

Published online by Cambridge University Press:  27 July 2023

By
James McKinlay  and
Alexander Fletcher
Edited by
Ned Gilbert-Kawai ,
Debashish Dutta  and
Carl Waldmann
Ned Gilbert-Kawai
Affiliation:
The Royal Liverpool Hospital
Debashish Dutta
Affiliation:
Princess Alexandra Hospital NHS Trust, Harlow
Carl Waldmann
Affiliation:
Royal Berkshire Hospital, Reading
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Summary

Key Learning Points

  1. 1. Antibiotic prophylaxis is used to prevent imminent/future infection.

  2. 2. Mostly importantly, it is used when a surgical implant is necessary.

  3. 3. A single dose can affect the gut flora and result in resistance.

  4. 4. Resistance to antibiotics is an ongoing problem.

  5. 5. New avenues are being trialled to reduce the problem of antibiotic resistance.

Keywords

resistanceprophylaxisnano-antibioticsphagebacteria
Type
Chapter
Information
Intensive Care Medicine
The Essential Guide
 , pp. 278 - 281
Publisher: Cambridge University Press
Print publication year: 2021

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References

References and Further Reading

Berríos-Torres, SI, Umscheid, CA, Bratzler, DW, et al. Centers for Disease Control and Prevention guideline for the prevention of surgical site infection, 2017. JAMA Surg 2017;152:784.Google Scholar
de Jonge, SW, Gans, SL, Atema, JJ, Solomkin, JS, Dellinger, PE, Boermeester, MA. Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection: a systematic review and meta-analysis. Medicine (Baltimore) 2017;96:e6903.CrossRefGoogle Scholar
Greenwood, D, Finch, R, Davey, P, Wilcox, M. Resistance to antimicrobial agents. In: Greenwood, D, Finch, R, Davey, P, Wilcox, M (eds). Antimicrobial Chemotherapy, 5th edn. Oxford: Oxford University Press; 2008. pp. 119–69.Google Scholar
Vincent, J-L, Bassetti, M, François, B, et al. Advances in antibiotic therapy in the critically ill. Crit Care 2016;20:133.CrossRefGoogle ScholarPubMed
Wright, GD. Q&A: Antibiotic resistance: where does it come from and what can we do about it? BMC Biol 2010;8:123.CrossRefGoogle Scholar

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