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3.7.12 - Antiviral Therapies

from Section 3.7 - Infection and Immunity

Published online by Cambridge University Press:  27 July 2023

By
James McKinlay  and
Alexander Fletcher
Edited by
Ned Gilbert-Kawai ,
Debashish Dutta  and
Carl Waldmann
Ned Gilbert-Kawai
Affiliation:
The Royal Liverpool Hospital
Debashish Dutta
Affiliation:
Princess Alexandra Hospital NHS Trust, Harlow
Carl Waldmann
Affiliation:
Royal Berkshire Hospital, Reading
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Summary

Key Learning Points

  1. 1. Viral infections are intracellular and more problematic in immunocompromised patients.

  2. 2. Apart from antiviral drugs, viral infections are also treated with immunomodulation.

  3. 3. Most serious viral infections in the intensive care unit involve the respiratory and/or neurological systems.

  4. 4. The mainstay of treatment of serious viral infections is supportive care.

  5. 5. Host toxicity from antivirals is likely due to the intracellular nature of infections.

Keywords

antiviralintracellularcoronavirusSARSimmune compromise
Type
Chapter
Information
Intensive Care Medicine
The Essential Guide
 , pp. 285 - 286
Publisher: Cambridge University Press
Print publication year: 2021

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References

References and Further Reading

Dandachi, D, Rodriguez-Barradas, MC. Viral pneumonia: etiologies and treatment. J Investig Med 2018;66:957–65.CrossRefGoogle ScholarPubMed
Dobson, J, Whitley, RJ, Pocock, S, Monto, AS. Oseltamivir treatment for influenza in adults: a meta-analysis of randomised controlled trials. Lancet 2015;385:1729–37.CrossRefGoogle ScholarPubMed
Greenwood, D, Finch, R, Davey, P, Wilcox, M (eds). Antimicrobial Chemotherapy, 5th edn. Oxford: Oxford University Press; 2008.Google Scholar
Kelesidis, T, Mastoris, I, Metsini, A, Tsiodras, S. How to approach and treat viral infections in ICU patients. BMC Infect Dis 2014;14:321.CrossRefGoogle ScholarPubMed

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