Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-10T15:04:12.047Z Has data issue: false hasContentIssue false

Chapter 24 - Drug synergy and therapeutic combinations

from Section 6 - The Management of Neuropathic Pain

Published online by Cambridge University Press:  05 December 2013

By
Stephan A. Schug
Edited by
Cory Toth  and
Dwight E. Moulin
Cory Toth
Affiliation:
Department of Neurology, University of Calgary
Dwight E. Moulin
Affiliation:
Department of Clinical Neurological Sciences, University of Western Ontario
Get access

Summary

This chapter assesses the current evidence for synergistic effects of medications in the treatment of neuropathic pain and the options for therapeutic combinations. There are currently a number of animal models, which are widely used to assess the efficacy of neuropathic pain treatments. Such animal models include streptozocin neuropathy as a potential model of peripheral neuropathy and sciatic nerve ligation described in a number of different models as a model of nerve injury. Many studies have consistently shown beneficial effects of combining two agents for the treatment of neuropathic pain, thereby supporting the rationale for combined treatment in humans. Most of the international treatment guidelines for neuropathic pain agree on a set of first-line treatments. These include topical lidocaine for localized peripheral neuropathic pain, antidepressants (Tricyclic antidepressants (TCAs) and Serotonin-norepinephrine reuptake inhibitors (SSNRIs)) and calcium channel alpha-2-delta ligands (gabapentin and pregabalin).

Keywords

tricyclic antidepressantsquality of lifesomatosensory cortexthalamusopioid analgesicsanticonvulsantcentral post-stroke pain
Type
Chapter
Information
Neuropathic Pain
Causes, Management and Understanding
 , pp. 290 - 298
Publisher: Cambridge University Press
Print publication year: 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×