Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-14T10:02:41.096Z Has data issue: false hasContentIssue false

Chapter 2 - Normal Coagulation Changes during Pregnancy

from Section 1 - Physiological Changes in Pregnancy

Published online by Cambridge University Press:  01 February 2018

By
Rachel Rayment
Edited by
Sue Pavord  and
Beverley Hunt
Sue Pavord
Affiliation:
University of Oxford
Beverley Hunt
Affiliation:
King's College London
Get access
Type
Chapter
Information
The Obstetric Hematology Manual , pp. 7 - 14
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Khan, RU, El-Refey, H. Pathophysiology of postpartum hemorrhage and the third stage of labor. In Arulkumaran, MKS, Keith, LG, Lalonde, AB, Lynch, CB, (eds). A Comprehensive Textbook of Postpartum Hemorrhage, 2nd edn. The Global Library of Women’s Medicine; 2012.Google Scholar
Wang, Y. Vascular Biology of the Placenta. Colloquium Series on Integrated Systems Physiology: From Molecule to Function 2010; 2(1): 1–98.Google Scholar
Harrison, RL, McKee, PA. Estrogen stimulates von Willebrand factor production by cultured endothelial cells. Blood 1984; 63(3): 657–664.CrossRefGoogle ScholarPubMed
Huq, FY, Kulkarni, A, Agbim, EC et al. Changes in the levels of factor VIII and von Willebrand factor in the puerperium. Hemophilia 2012; 18(2): 241–245.Google Scholar
Gernsheimer, T, James, AH, Stasi, R. How I treat thrombocytopenia in pregnancy. Blood 2013; 121(1): 38–47.CrossRefGoogle Scholar
McLean, KC, Bernstein, IM, Brummel-Ziedins, KE. Tissue factor-dependent thrombin generation across pregnancy. American Journal of Obstetrics and Gynecology 2012; 207(2): 135.e1–6.Google Scholar
Hammerova, L, Chabada, J, Drobny, J et al. Longitudinal evaluation of markers of hemostasis in pregnancy. Bratisl Lek Listy 2014; 115(3): 140–144.Google ScholarPubMed
Comeglio, P, Fedi, S, Liotta, A et al. Blood clotting activation during normal pregnancy. Thrombosis Research 1996; 84(3): 199–202.Google Scholar
de Boer, KW, ten Cate, J, Sturk, A et al. Enhanced thrombin generation in normal and hypertensive pregnancy. American Journal of Obstetrics and Gynecology 1989; 160(1): 95–100.Google Scholar
Dahlman, T, Hellgren, M, Blomback, M. Changes in blood coagulation and fibrinolysis in the normal puerperium. Gynecologic and Obstetric Investigation 1985; 20(1): 37–44.CrossRefGoogle ScholarPubMed
Hiippala, ST, Myllyla, GJ, Vahtera, EM. Hemostatic factors and replacement of major blood loss with plasma-poor red cell concentrates. Anesthesia and Analgesia 1995; 81(2): 360–365.Google Scholar
Charbit, B, Mandelbrot, L, Samain, E et al. The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage. Journal of Thrombosis and Haemostasis 2007; 5(2): 266–273.CrossRefGoogle ScholarPubMed
Sharief, LT, Kadir, R, Smith, C et al. Changes in factor XIII level during pregnancy. Hemophilia 2014; 20(2): E144–E148.CrossRefGoogle ScholarPubMed
Brenner, B. Hemostatic changes in pregnancy. Thrombosis Research 2004; 114(5–6): 409–414.Google Scholar
Kruithof, EK, Tran-Thang, C, Gudinchet, A et al. Fibrinolysis in pregnancy: a study of plasminogen activator inhibitors. Blood 1987; 69(2): 460–466.Google Scholar
Choi, JW, Pai, SH. Tissue plasminogen activator levels change with plasma fibrinogen concentrations during pregnancy. Annals of Hematology 2002; 81(11): 611–615.Google ScholarPubMed
Kovac, M Mikovic, Z, Rakicevic, L et al. The use of D-dimer with new cutoff can be useful in diagnosis of venous thromboembolism in pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology 2010; 148(1): 27–30.CrossRefGoogle ScholarPubMed
Bajzar, L. Thrombin activatable fibrinolysis inhibitor and an antifibrinolytic pathway. Arteriosclerosis Thrombosis and Vascular Biology 2000; 20(12): 2511–2518.CrossRefGoogle Scholar
Hellgren, M. Hemostasis during normal pregnancy and puerperium. Seminars in Thrombosis and Hemostasis 2003; 29(2): 125–130.CrossRefGoogle ScholarPubMed
Stimson, WH, Farquharson, DM, Lang, GD. Pregnancy-associated alpha 2-macroglobulin – a new serum protein elevated in normal human pregnancy. Journal of Reproductive Immunology 1983; 5(6): 321–327.Google Scholar
Saha, P, Stott, D, Atalla, R. Hemostatic changes in the puerperium ‘6 weeks postpartum’ (HIP Study) – implication for maternal thromboembolism. British Journal of Obstetrics and Gynaecology 2009; 116(12): 1602–1612.CrossRefGoogle ScholarPubMed
Comp, PC, Thurnau, GR, Welsh, J et al. Functional and immunologic protein S levels are decreased during pregnancy. Blood 1986; 68(4): 881–885.CrossRefGoogle ScholarPubMed
Mahieu B, B, Jacobs, N, Mahieu, S et al. Hemostatic changes and acquired activated protein C resistance in normal pregnancy. Blood Coagulation and Fibrinolysis 2007; 18(7): 685–688.CrossRefGoogle ScholarPubMed
Godoi, LC, Gomes, K, Alpoim, P et al. Preeclampsia: the role of tissue factor and tissue factor pathway inhibitor. Journal of Thrombosis and Thrombolysis 2012; 34(1): 1–6.Google Scholar
de Lloyd, L, Bovington, R, Kaye, A et al. Standard hemostatic tests following major obstetric hemorrhage. International Journal of Obstetric Anesthesia 2011; 20(2): 135–141.CrossRefGoogle Scholar
Mackie, IJ, Kitchen, S, Machin, SJ et al. Guidelines on fibrinogen assays. British Journal of Hematology 2003; 121(3): 396–404.CrossRefGoogle ScholarPubMed
Whiting, D, DiNardo, JA. TEG and ROTEM: technology and clinical applications. American Journal of Hematology 2014; 89(2): 228–232.Google Scholar
Karlsson, O, Sporrong, T, Hillarp, A et al. Prospective longitudinal study of thromboelastography and standard hemostatic laboratory tests in healthy women during normal pregnancy. Anesthesia and Analgesia 2012; 115(4): 890–898.Google Scholar
Polak, F, Kolnikova, I, Lips, M et al. New recommendations for thromboelastography reference ranges for pregnant women. Thrombosis Research 2011; 128(4): E14–17.Google Scholar
Karlsson, O, Jeppsson, A, Hellgren, M. Major obstetric hemorrhage: monitoring with thromboelastography, laboratory analyses or both? International Journal of Obstetric Anesthesia 2014; 23(1): 10–17.CrossRefGoogle ScholarPubMed
Armstrong, S, Fernando, S, Ashpole, K et al. Assessment of coagulation in the obstetric population using ROTEM(R) thromboelastometry. International Journal of Obstetric Anesthesia 2011; 20(4): 293–298.CrossRefGoogle Scholar
Collins, PW, Lilley, G, Bruynseels, D et al. Fibrin-based clot formation as an early and rapid biomarker for progression of postpartum hemorrhage: a prospective study. Blood 2014; 124(11): 1727–1736.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×