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Chapter 14 - Is It Likely That Reproductive Aging Could Be Delayed or Reversed Using Advanced Technologies in the Future?

from Section 9 - New Technologies

Published online by Cambridge University Press:  15 September 2022

By
Paula Amato  and
Dimitrios S. Nikolaou
Edited by
Dimitrios S. Nikolaou  and
David B. Seifer
Dimitrios S. Nikolaou
Affiliation:
Chelsea and Westminster Hospital, London
David B. Seifer
Affiliation:
Yale Reproductive Medicine, New Haven, CT
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Summary

This chapter explores new technologies for overcoming the problem of deteriorating oocyte-quality with age. It includes brief discussions of the following: mitochondrial replacement therapy, cytoplasmic transfer, autologous germline mitochondrial energy transfer (AUGMENT), maternal spindle transfer (MTS), in vitro activation of dormant follicles, autologous activated platelet-rich plasma injections (PRP), in vitro gametogenesis, induced pluripotent stem cells (iPSCs), aneuploidy correction through gene-editing and artificial ovaries. Clinicians should exercise extreme caution in managing patient expectations regarding these novel technologies. While clinical application of stem cell technology for maternal age-related infertility does seem likely at some point in the future, the timeline remains uncertain.

Keywords

Mitochondrial replacement therapycytoplasmic transferAUGMENTmaternal spindle transfer (MTS)in-vitro activation of dormant folliclesautologous activated platelet-rich plasma injections (PRP)in-vitro gametogenesisinduced pluripotent stem cells (iPSCs)
Type
Chapter
Information
Optimizing the Management of Fertility in Women over 40 , pp. 163 - 172
Publisher: Cambridge University Press
Print publication year: 2022

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