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Chapter 71 - Cervical Cancer in Pregnancy

from Section 12 - Malignant Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Oded Raban ,
Amira El-Messidi  and
Walter H. Gotlieb
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

You are covering an obstetrics clinic for your colleague, who left for vacation last week. A healthy 32-year-old primigravida at 13+4 weeks’ gestation called for an emergency appointment after experiencing two episodes of postcoital bleeding over the past week. She met your colleague last week at her first prenatal visit, which was unremarkable. Sonographic dating was appropriate for menstrual age, and first-trimester fetal anatomy was normal. You note that all routine prenatal serum laboratory investigations are normal with low-risk screening tests for fetal aneuploidy. Without a cervical smear in over two years, cytology was performed, and results are expected shortly.

Keywords

Cervical cancer, stages, pregnancyClinical presentationPhysical examinationInvestigations, diagnosis, evaluation, colposcopy, magnetic resonance imaging, positron emission tomographyPrenatal counselingMicroinvasive squamous carcinoma, obstetric deliveryInvasive squamous carcinoma, obstetric deliveryNeoadjuvant chemotherapy (NACT), cisplatin, paclitaxelConization, cone-cercalge, cervical coneWhole pelvic, external beam radiotherapyObstetric delivery recommendations
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 898 - 908
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Amant, F, Berveiller, P, Boere, IA, et al. Gynecologic cancers in pregnancy: guidelines based on a third international consensus meeting. Ann Oncol. 2019;30(10):1601–1612.CrossRefGoogle ScholarPubMed
Beharee, N, Shi, Z, Wu, D, et al. Diagnosis and treatment of cervical cancer in pregnant women. Cancer Med. 2019;8(12):5425–5430.CrossRefGoogle ScholarPubMed
Bigelow, CA, Horowitz, NS, Goodman, A, et al. Management and outcome of cervical cancer diagnosed in pregnancy. Am J Obstet Gynecol. 2017;216(3): 276.e1–276.e6.CrossRefGoogle ScholarPubMed
Cordeiro, CN, Gemignani, ML. Gynecologic malignancies in pregnancy: balancing fetal risks with oncologic safety. Obstet Gynecol Surv. 2017;72(3):184–193.CrossRefGoogle ScholarPubMed
de Haan, J, Verheecke, M, Van Calsteren, K, et al. Oncological management and obstetric and neonatal outcomes for women diagnosed with cancer during pregnancy: a 20-year international cohort study of 1170 patients. Lancet Oncol. 2018;19(3):337–346.Google Scholar
Hecking, T, Abramian, A, Domröse, C, et al. Individual management of cervical cancer in pregnancy. Arch Gynecol Obstet. 2016;293(5):931–939.CrossRefGoogle ScholarPubMed
Hunter, MI, Tewari, K, Monk, BJ. Cervical neoplasia in pregnancy. Part 2: current treatment of invasive disease. Am J Obstet Gynecol. 2008;199(1):10–18.CrossRefGoogle ScholarPubMed
Korenaga, TK, Tewari, KS. Gynecologic cancer in pregnancy. Gynecol Oncol. 2020;157(3):799–809.CrossRefGoogle ScholarPubMed
Perrone, AM, Bovicelli, A, D’Andrilli, G, et al. Cervical cancer in pregnancy: analysis of the literature and innovative approaches. J Cell Physiol. 2019;234(9):14975–14990.CrossRefGoogle ScholarPubMed
Yoshihara, K, Ishiguro, T, Chihara, M, et al. The safety and effectiveness of abdominal radical trachelectomy for early-stage cervical cancer during pregnancy. Int J Gynecol Cancer. 2018;28(4):782–787.CrossRefGoogle ScholarPubMed

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