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Chapter 73 - Lymphoma and Leukemia in Pregnancy

from Section 12 - Malignant Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Samantha So ,
Amira El-Messidi  and
Elyce H. Cardonick
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

You are seeing a patient referred by her primary care provider for consultation at your tertiary center’s high-risk obstetrics unit. She is a 27-year-old primigravida at 16+3 weeks’ gestation with intermittent swelling of her arms and face that appears within several minutes of brushing her hair and resolves upon lowering her arms. First-trimester dating sonography was concordant with menstrual dates, and fetal morphology appeared normal, with a low risk of aneuploidy; apart from HIV-negative status, results of other routine baseline prenatal investigations are not yet available to you. She has not experienced abdominal cramps or vaginal bleeding. Her medications include only routine prenatal vitamins.

Keywords

PregnancyLymphoma, Hodgkin’s and non-Hodgkin’sLeukemiaClinical presentationSerum investigationImaging, chest X-ray, fetal considerationsPerinatal risks, complications, maternal-fetal morbidity, adverse outcomeAntepartum, intrapartum, postpartum managementChemotherapyTumor lysis syndrome, eclampsia
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 922 - 936
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Brenner, B, Avivi, I, Lishner, M. Haematological cancers in pregnancy. Lancet. 2012;379(9815):580–587.CrossRefGoogle ScholarPubMed
Cardonick, EH, Gringlas, MB, Hunter, K, et al. Development of children born to mothers with cancer during pregnancy: comparing in utero chemotherapy-exposed children with nonexposed controls. Am J Obstet Gynecol. 2015;212(5):658.Google Scholar
Cardonick, E, Iacobucci, A. Use of chemotherapy during human pregnancy. Lancet Oncol. 2004;5(5):283–291.CrossRefGoogle ScholarPubMed
Cohen, JB, Blum, KA. Evaluation and management of lymphoma and leukemia in pregnancy. Clin Obstet Gynecol. 2011;54(4):556–566.Google Scholar
El-Messidi, A, Patenaude, V, Abenhaim, HA. Incidence and outcomes of women with non-Hodgkin’s lymphoma in pregnancy: a population-based study on 7.9 million births. J Obstet Gynaecol Res. 2015;41(4):582–589.CrossRefGoogle Scholar
El-Messidi, A, Patenaude, V, Hakeem, G, et al. Incidence and outcomes of women with Hodgkin’s lymphoma in pregnancy: a population-based study on 7.9 million births. J Perinat Med. 2015;43(6):683–688.CrossRefGoogle Scholar
Evens, AM, Advani, R, Press, OW, et al. Lymphoma occurring during pregnancy: antenatal therapy, complications, and maternal survival in a multicenter analysis. J Clin Oncol. 2013;31(32):4132–4139.CrossRefGoogle Scholar
Gurevich-Shapiro, A, Avivi, I. Current treatment of lymphoma in pregnancy. Expert Rev Hematol. 2019;12(6):449–459.CrossRefGoogle ScholarPubMed
Lishner, M, Avivi, I, Apperley, JF, et al. Hematologic malignancies in pregnancy: management guidelines from an international consensus meeting. J Clin Oncol. 2016;34(5):501–508.Google Scholar
Maggen, C, Dierickx, D, Lugtenburg, P, et al. Obstetric and maternal outcomes in patients diagnosed with Hodgkin lymphoma during pregnancy: a multicentre, retrospective, cohort study. Lancet Haematol. 2019;6(11):e551–e561. [Correction in Lancet Haematol. 2020 Apr;7(4):e279]Google Scholar

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