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Chapter 5 - Immune Complex Mediated Glomerular Diseases

from Section 2 - Glomerular Diseases

Published online by Cambridge University Press:  10 August 2023

By
Pablo Cannata
Edited by
Helen Liapis
Helen Liapis
Affiliation:
Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
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Summary

In many diseases, etiopathogenesis relies on dysregulation of the immune system – either secondary to a recognized underlying condition or primary due to an unknown cause ؘ– that will lead to a wide spectrum of glomerular disorders and a broad range of clinical symptoms from nephritic to nephrotic syndrome. This chapter outlines the most important clinicopathological entities related to immune-complex formation. Recent advances in our understanding of the role of complement in the pathogenesis of many immune-complex mediated diseases have led to the description of new diseases and novel classifications based more on the etiopathogenesis than on pure morphological findings. We briefly discuss the pathogenesis of immune-complex mediated diseases, now expanding to include genetics and/or genetic susceptibility, which are influencing patient management.

Keywords

IgA nephropathy (IgAN)post-infectious glomerulonephritis (PIGN)membranous glomerulonephritis (MGN)IgGIgMC3C1q glomerulopathymembranoproliferative glomerulonephritis (MPGN)lupus nephritis (LN)
Type
Chapter
Information
Pediatric Nephropathology & Childhood Kidney Tumors , pp. 87 - 120
Publisher: Cambridge University Press
Print publication year: 2023

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  • Immune Complex Mediated Glomerular Diseases
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book: Pediatric Nephropathology & Childhood Kidney Tumors
  • Online publication: 10 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781108907224.006
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  • Immune Complex Mediated Glomerular Diseases
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book: Pediatric Nephropathology & Childhood Kidney Tumors
  • Online publication: 10 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781108907224.006
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  • Immune Complex Mediated Glomerular Diseases
  • Edited by Helen Liapis, Ludwig Maximilian University, Nephrology Center, Munich, Adjunct Professor and Washington University St Louis, Department of Pathology and Immunology, Retired Professor
  • Book: Pediatric Nephropathology & Childhood Kidney Tumors
  • Online publication: 10 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781108907224.006
Available formats
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