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Chapter 10 - Molecular aspects of follicular development

from Section 3 - Reproductive biology and cryobiology

Published online by Cambridge University Press:  04 February 2011

By
Zhongwei Huang  and
Dagan Wells
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Université Catholique de Louvain, Belgium
S. Samuel Kim
Affiliation:
University of Kansas
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Summary

The follicle has a fundamental reproductive role in the ovary. Follicle growth takes 85 days in humans and most follicles become artistic at some stage with the oocyte continuing to play a critical role in follicular control and the regulation of oogenesis, ovulation rate and fecundity. The first primordial follicle in human foetuses is formed at 15-22 week gestation, at which point oocytes are enclosed by a single layer of pre-granulosa cells. Upon activation of primordial follicles, progression from the primary to secondary stage of follicular development requires further oocyte expansion, granulosa cell (GC) proliferation and investment of a luteinizing hormone (LH)-responsive theca cell layer. The pre-antral follicle continues its development and becomes increasingly follicle stimulating hormone (FSH) responsive. Follicular antrum formation and antral expansion are absolutely dependent on FSH. Luteinizing hormone appears to play a major role in mediating the final phase of follicular development.

Keywords

cancerchemotherapycyclophosphamidesurgeryradiotherapynon-growing folliclesovarian damagetestes
Type
Chapter
Information
Principles and Practice of Fertility Preservation , pp. 114 - 128
Publisher: Cambridge University Press
Print publication year: 2011

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