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Chapter 8.2 - Cerebral Amyloid Angiopathy

from 8 - Other Non-inflammatory Vasculopathies

Published online by Cambridge University Press:  06 October 2022

Anita Arsovska
By
Matija Zupan
Edited by
Derya Uluduz
Anita Arsovska
Affiliation:
University of Ss Cyril and Methodius
Derya Uluduz
Affiliation:
Istanbul Üniversitesi
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Summary

Cerebral amyloid angiopathy (CAA) is characterised by the deposition of Aß proteins in the media and adventitia of small and mid-sized cortical and leptomeningeal arteries (and, less frequently, veins). It is a component of any disorder in which amyloid is deposited in the brain, and it is not associated with systemic amyloidosis. The prevalence of CAA increases with advancing age. Some autopsy series have found CAA in 5% of individuals in the seventh decade but in 50% of those older than 90 years. While often asymptomatic, CAA is being increasingly recognised as an important cause of ICH in the elderly, accounting for up to one-fifth of all spontaneous ICH in this group. We present an 82 year-old gentleman who was diagnosed with cSAH and fulfilled the criteria for probable CAA

Keywords

cerebral amyloid angiopathysubarachnoidal haemorrhageamyloidintracerebral haemorrhageAß proteins
Type
Chapter
Information
Rare Causes of Stroke
A Handbook
 , pp. 314 - 320
Publisher: Cambridge University Press
Print publication year: 2022

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References

Greenberg, SM, Bacskai, BJ, Hernandez-Guillamon, M, et al. Cerebral amyloid angiopathy and Alzheimer disease: One peptide, two pathways. Nat Rev Neurol. 2020;16(1): 30–42.CrossRefGoogle ScholarPubMed
Sharma, R, Dearaugo, S, Infeld, B, O’Sullivan, R, Gerraty, RP. Cerebral amyloid angiopathy: Review of clinico-radiological features and mimics. J Med Imaging Radiat Oncol. 2018. doi: 10.1111/1754–9485.12726. Online ahead of print.CrossRefGoogle Scholar
Banerjee, G, Carare, R, Cordonnier, C, et al. The increasing impact of cerebral amyloid angiopathy: essential new insights for clinical practice. J Neurol Neurosurg Psychiatry. 2017;88(11): 982–994.CrossRefGoogle ScholarPubMed
Greenberg, SM, Charidimou, A. Diagnosis of cerebral amyloid angiopathy: Evolution of the Boston criteria. Stroke. 2018;49: 491–497.CrossRefGoogle ScholarPubMed

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