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Chapter 1.2 - Chapter

from 1 - Inflammatory Conditions

Published online by Cambridge University Press:  06 October 2022

Anita Arsovska
Edited by
Derya Uluduz
Anita Arsovska
Affiliation:
University of Ss Cyril and Methodius
Derya Uluduz
Affiliation:
Istanbul Üniversitesi
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Summary

Lymphomatoid granulomatosis is rare EBV mediated lymphoproliferative disorder occurring within the 4th to 6th decade, with most risk factors relating to an immunocompromised state. Histological analysis shows an angiocentric and angiodestructive infiltrate with varying degrees of necrosis and atypical EBV positive cells. The lungs are the primary site of involvement in over 90% of cases but central nervous system involvement can occur alongside or in isolation. Neurological presentation is varied and MRI commonly displays focal white matter parenchymal lesions. A brain biopsy may be required to exclude competing diagnoses or in the absence of identifiable disease elsewhere. Treatment depends on stage of disease and can range from observation, withdrawal of immunosuppressive regimes or aggressive chemo/immunotherapy

Keywords

Lymphomatoid granulomatosislymphoproliferative disorderimmunocompromisedimmunosuppressiveimmunotherapy
Type
Chapter
Information
Rare Causes of Stroke
A Handbook
 , pp. 40 - 44
Publisher: Cambridge University Press
Print publication year: 2022

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References

Liebow, AA, Carrington, CR, Friedman, PJ. Lymphomatoid granulomatosis. Hum Pathol. 1972;3(4): 457–558.CrossRefGoogle ScholarPubMed
Dunleavy, K, Roschewski, M, Wilson, WH. Lymphomatoid granulomatosis and other Epstein-Barr virus associated lymphoproliferative processes. Curr Hematol Malig Rep. 2012;7(3): 208–215.CrossRefGoogle ScholarPubMed
Song, JY, Pittaluga, S, Dunleavy, K, et al. Lymphomatoid granulomatosis – a single institute experience: pathologic findings and clinical correlations. Am J Surg Pathol. 2015;39(2): 141–156.CrossRefGoogle ScholarPubMed
Sukswai, N, Lyapichev, K, Khoury, JD, Medeiros, LJ. Diffuse large B-cell lymphoma variants: an update. Pathology. 2020;52(1): 53–67.CrossRefGoogle ScholarPubMed
Dojcinov, SD, Fend, F, Quintanilla-Martinez, L. EBV-positive lymphoproliferations of B-T-and NK-cell derivation in non-immunocompromised hosts. Pathogens. 2018;7(1): 28.CrossRefGoogle Scholar
Melani, C, Jaffe, ES, Wilson, WH. Pathobiology and treatment of lymphomatoid granulomatosis, a rare EBV-driven disorder. Blood. 2020;135(16): 1344–1352.CrossRefGoogle ScholarPubMed
Roschewski, M, Wilson, WH. EBV-associated lymphomas in adults. Best Pract Res Clin Haematol. 2012;25(1): 75–89.CrossRefGoogle ScholarPubMed
Patsalides, AD, Atac, G, Hedge, U, et al. Lymphomatoid granulomatosis: abnormalities of the brain at MR imaging. Radiology. 2005;237(1): 265–273.CrossRefGoogle Scholar
Katzenstein, AL, Doxtader, E, Narendra, S. Lymphomatoid granulomatosis: insights gained over 4 decades. Am J Surgical Pathol. 2010;34(12): e35–e48.CrossRefGoogle ScholarPubMed
Rezk, SA, Weiss, LM. EBV–associated lymphoproliferative disorders: update in classification. Surg Pathol Clin. 2019;12(3): 745–770.CrossRefGoogle ScholarPubMed
Kim, JY, Jung, KC, Park, SH, Choe, JY, Kim, JE. Primary lymphomatoid granulomatosis in the central nervous system: A report of three cases. Neuropathology. 2018;38(4): 331–336.CrossRefGoogle Scholar
Koeller, KK, Shih, RY. Extranodal lymphoma of the central nervous system and spine. Radiol Clin North Am. 2016;54(4): 649–671.CrossRefGoogle ScholarPubMed
Oliveras, C, D’Olhaberriague, L, Garcia, J, Matias-Guiu, X. Parkinsonism as first manifestation of lymphomatoid granulomatosis. J Neurol Neurosurg Psychiatry. 1988;51(7): 999.CrossRefGoogle ScholarPubMed
Borie, R, Wislez, M, Antoine, M, Cadranel, J. Lymphoproliferative disorders of the lung. Respiration. 2017;94(2): 157–175.CrossRefGoogle ScholarPubMed
Tateishi, U, Terae, S, Ogata, A, et al. MR imaging of the brain in lymphomatoid granulomatosis. Am J Neuroradiol. 2001;22(7): 1283–1290.Google ScholarPubMed
Yang, M, Rosenthal, AC, Ashman, JB, Craig, FE. The role and pitfall of F18-FDG PET/CT in surveillance of high grade pulmonary lymphomatoid granulomatosis. Curr Probl Diagn Radiol. 2021;50(3): 443–449.CrossRefGoogle ScholarPubMed
Zhang, YX, Ding, MP, Zhang, T, et al. Lymphomatoid granulomatosis with CNS involvement can lead to spontaneous remission: case study. CNS Neurosci Ther. 2013;19(7): 536.CrossRefGoogle ScholarPubMed
Aiko, N, Sekine, A, Umeda, S, et al. The spontaneous regression of grade 3 methotrexate-related lymphomatoid granulomatosis: a case report and literature review. Intern Med. 2018;57(21): 3163–3167.CrossRefGoogle ScholarPubMed
Tang, VK, Vijhani, P, Cherian, SV, et al. Primary pulmonary lymphoproliferative neoplasms. Lung India. 2018;35(3): 220–230.Google ScholarPubMed
Katzenstein, AL, Carrington, CB, Liebow, AA: Lymphomatoid granulomatosis: a clinicopathologic study of 152 cases. Cancer. 1979;43: 360–373.3.0.CO;2-8>CrossRefGoogle ScholarPubMed

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  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.008
Available formats
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  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.008
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book: Rare Causes of Stroke
  • Online publication: 06 October 2022
  • Chapter DOI: https://doi.org/10.1017/9781108902793.008
Available formats
×