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9 - Functional Magnetic Resonance Imaging Studies of Obsessive-Compulsive and Related Disorders

from Section 1 - Theoretical Foundations of Obsessive-Compulsive and Related Disorders

Published online by Cambridge University Press:  14 December 2018

By
Jaewook Han  and
Jun Soo Kwon
Edited by
Leonardo F. Fontenelle  and
Murat Yücel
Leonardo F. Fontenelle
Affiliation:
Federal University of Rio de Janeiro
Murat Yücel
Affiliation:
Monash University, Victoria
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A Transdiagnostic Approach to Obsessions, Compulsions and Related Phenomena , pp. 85 - 112
Publisher: Cambridge University Press
Print publication year: 2019

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References

Beucke, JC, Sepulcre, J, Buhlmann, U, Kathmann, N, Moody, T, Feusner, JD. Degree connectivity in body dysmorphic disorder and relationships with obsessive and compulsive symptoms. Eur Neuropsychopharmacol. 2016;26(10):1657–1666.Google Scholar
Moody, TD, Sasaki, MA, Bohon, C, et al. Functional connectivity for face processing in individuals with body dysmorphic disorder and anorexia nervosa. Psychol Med. 2015;45(16):3491–3503.Google Scholar
Via, E, Cardoner, N, Pujol, J, et al. Amygdala activation and symptom dimensions in obsessive-compulsive disorder. Br J Psychiatry. 2014;204(1):61–68.CrossRefGoogle ScholarPubMed
Jhung, K, Ku, J, Kim, SJ, et al. Distinct functional connectivity of limbic network in the washing type obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;53:149–155.Google Scholar
Simon, D, Adler, N, Kaufmann, C, Kathmann, N. Amygdala hyperactivation during symptom provocation in obsessive–compulsive disorder and its modulation by distraction. Neuroimage Clin. 2014;4:549–557.Google Scholar
Milad, MR, Furtak, SC, Greenberg, JL, et al. Deficits in conditioned fear extinction in obsessive-compulsive disorder and neurobiological changes in the fear circuit. JAMA Psychiatry. 2013;70(6):608–618.Google Scholar
Weygandt, M, Blecker, CR, Schäfer, A, et al. fMRI pattern recognition in obsessive-compulsive disorder. Neuroimage. 2012;60(2):1186–1193.CrossRefGoogle ScholarPubMed
Bohon, C, Hembacher, E, Moller, H, Moody, TD, Feusner, JD. Nonlinear relationships between anxiety and visual processing of own and others’ faces in body dysmorphic disorder. Psychiatry Res. 2012;204(2–3):132–139.Google Scholar
Feusner, JD, Hembacher, E, Moller, H, Moody, TD. Abnormalities of object visual processing in body dysmorphic disorder. Psychol Med. 2011;41(11):2385–2397.CrossRefGoogle ScholarPubMed
Lee, JA, Kim, CK, Jahng, GH, et al. A pilot study of brain activation in children with trichotillomania during a visual-tactile symptom provocation task: a functional magnetic resonance imaging study. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(7):1250–1258.Google Scholar
An, SK, Mataix-Cols, D, Lawrence, NS, et al. To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder. Mol Psychiatry. 2009;14(3):318–331.Google Scholar
Lawrence, NS, An, SK, Mataix-Cols, D, Ruths, F, Speckens, A, Phillips, ML. Neural responses to facial expressions of disgust but not fear are modulated by washing symptoms in OCD. Biol Psychiatry. 2007;61(9):1072–1080.Google Scholar
Feusner, JD, Townsend, J, Bystritsky, A, Bookheimer, S. Visual information processing of faces in body dysmorphic disorder. Arch Gen Psychiatry. 2007;64(12):1417–1425.Google Scholar
Schienle, A, Schafer, A, Stark, R, Walter, B, Vaitl, D. Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures. Int J Psychophysiol. 2005;57(1):69–77.CrossRefGoogle ScholarPubMed
Mataix-Cols, D, Wooderson, S, Lawrence, N, Brammer, MJ, Speckens, A, Phillips, ML. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiatry. 2004;61(6):564–576.Google Scholar
Cannistraro, PA, Wright, CI, Wedig, MM, et al. Amygdala responses to human faces in obsessive-compulsive disorder. Biol Psychiatry. 2004;56(12):916–920.Google Scholar
Shapira, NA, Liu, Y, He, AG, et al. Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. Biol Psychiatry. 2003;54(7):751–756.CrossRefGoogle ScholarPubMed
Adler, CM, McDonough-Ryan, P, Sax, KW, Holland, SK, Arndt, S, Strakowski, SM. fMRI of neuronal activation with symptom provocation in unmedicated patients with obsessive compulsive disorder. J Psychiatr Res. 2000;34(4–5):317–324.Google Scholar
Phillips, ML, Marks, IM, Senior, C, et al. A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust. Psychol Med. 2000;30(5):1037–1050.CrossRefGoogle ScholarPubMed
Breiter, HC, Rauch, SL, Kwong, KK, et al. Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Arch Gen Psychiatry. 1996;53(7):595–606.Google Scholar
Hough, CM, Luks, TL, Lai, K, et al. Comparison of brain activation patterns during executive function tasks in hoarding disorder and non-hoarding OCD. Psychiatry Res. 2016;255:50–59.CrossRefGoogle ScholarPubMed
Morein-Zamir, S, Voon, V, Dodds, CM, et al. Divergent subcortical activity for distinct executive functions: stopping and shifting in obsessive compulsive disorder. Psychol Med. 2016;46(4):829–840.Google Scholar
Odlaug, BL, Hampshire, A, Chamberlain, SR, Grant, JE. Abnormal brain activation in excoriation (skin-picking) disorder: evidence from an executive planning fMRI study. Br J Psychiatry. 2016;208(2):168–174.Google Scholar
Han, HJ, Jung, WH, Yun, JY, et al. Disruption of effective connectivity from the dorsolateral prefrontal cortex to the orbitofrontal cortex by negative emotional distraction in obsessive-compulsive disorder. Psychol Med. 2016;46(5):921–932.Google Scholar
Weidt, S, Lutz, J, Rufer, M, et al. Common and differential alterations of general emotion processing in obsessive-compulsive and social anxiety disorder. Psychol Med. 2016;46(7):1427–1436.Google Scholar
van Velzen, LS, de Wit, SJ, Ćurĉić-Blake, B, et al. Altered inhibition-related frontolimbic connectivity in obsessive-compulsive disorder. Hum Brain Mapp. 2015;36(10):4064–4075.Google Scholar
Marsh, R, Tau, GZ, Wang, Z, et al. Reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder. Am J Psychiatry. 2015;172(4):383–392.Google Scholar
Gillan, CM, Apergis-Schoute, AM, Morein-Zamir, S, et al. Functional neuroimaging of avoidance habits in obsessive-compulsive disorder. Am J Psychiatry. 2015;172(3):284–293.CrossRefGoogle ScholarPubMed
Rotge, JY, Langbour, N, Dilharreguy, B, et al. Contextual and behavioral influences on uncertainty in obsessive-compulsive disorder. Cortex. 2015;62:1–10.Google Scholar
Tolin, DF, Witt, ST, Stevens, MC. Hoarding disorder and obsessive-compulsive disorder show different patterns of neural activity during response inhibition. Psychiatry Res. 2014;221(2):142–148.Google Scholar
Marsh, R, Horga, G, Parashar, N, Wang, Z, Peterson, BS, Simpson, HB. Altered activation in fronto-striatal circuits during sequential processing of conflict in unmedicated adults with obsessive-compulsive disorder. Biol Psychiatry. 2014;75(8):615–622.Google Scholar
de Vries, FE, de Wit, SJ, Cath, DC, et al. Compensatory frontoparietal activity during working memory: an endophenotype of obsessive-compulsive disorder. Biol Psychiatry. 2014;76(11):878–887.Google Scholar
Agam, Y, Greenberg, JL, Isom, M, et al. Aberrant error processing in relation to symptom severity in obsessive-compulsive disorder: a multimodal neuroimaging study. Neuroimage Clin. 2014;5:141–151.Google Scholar
Kang, DH, Jang, JH, Han, JY, et al. Neural correlates of altered response inhibition and dysfunctional connectivity at rest in obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:340–346.CrossRefGoogle ScholarPubMed
White, MP, Shirer, WR, Molfino, MJ, Tenison, C, Damoiseaux, JS, Greicius, MD. Disordered reward processing and functional connectivity in trichotillomania: a pilot study. J Psychiatr Res. 2013;47(9):1264–1272.Google Scholar
Jung, WH, Kang, DH, Kim, E, Shin, KS, Jang, JH, Kwon, JS. Abnormal corticostriatal-limbic functional connectivity in obsessive-compulsive disorder during reward processing and resting-state. Neuroimage Clin. 2013;3:27–38.Google Scholar
Stern, ER, Welsh, RC, Gonzalez, R, Fitzgerald, KD, Abelson, JL, Taylor, SF. Subjective uncertainty and limbic hyperactivation in obsessive-compulsive disorder. Hum Brain Mapp. 2013;34(8):1956–1970.CrossRefGoogle ScholarPubMed
de Wit, SJ, de Vries, FE, van der Werf, YD, et al. Presupplementary motor area hyperactivity during response inhibition: a candidate endophenotype of obsessive-compulsive disorder. Am J Psychiatry. 2012;169(10):1100–1108.Google Scholar
Tolin, DF, Stevens, MC, Villavicencio, AL, et al. Neural mechanisms of decision making in hoarding disorder. Arch Gen Psychiatry. 2012;69(8):832–841.CrossRefGoogle ScholarPubMed
Harrison, BJ, Pujol, J, Soriano-Mas, C, et al. Neural correlates of moral sensitivity in obsessive-compulsive disorder. Arch Gen Psychiatry. 2012;69(7):741–749.Google Scholar
Cocchi, L, Harrison, BJ, Pujol, J, et al. Functional alterations of large-scale brain networks related to cognitive control in obsessive-compulsive disorder. Hum Brain Mapp. 2012;33(5):1089–1106.Google Scholar
van den Heuvel, OA, Mataix-Cols, D, Zwitser, G, et al. Common limbic and frontal-striatal disturbances in patients with obsessive compulsive disorder, panic disorder and hypochondriasis. Psychol Med. 2011;41(11):2399–2410.Google Scholar
Jung, WH, Kang, DH, Han, JY, et al. Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder. Acta Psychiatr Scand. 2011;123(5):376–386.Google Scholar
Stern, ER, Welsh, RC, Fitzgerald, KD, et al. Hyperactive error responses and altered connectivity in ventromedial and frontoinsular cortices in obsessive-compulsive disorder. Biol Psychiatry. 2011;69(6):583–591.CrossRefGoogle ScholarPubMed
Figee, M, Vink, M, de Geus, F, et al. Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatry. 2011;69(9):867–874.Google Scholar
Rubia, K, Cubillo, A, Smith, AB, Woolley, J, Heyman, I, Brammer, MJ. Disorder-specific dysfunction in right inferior prefrontal cortex during two inhibition tasks in boys with attention-deficit hyperactivity disorder compared to boys with obsessive-compulsive disorder. Hum Brain Mapp. 2010;31(2):287–299.CrossRefGoogle ScholarPubMed
Schlösser, RG, Wagner, G, Schachtzabel, C, et al. Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling. Hum Brain Mapp. 2010;31(12):1834–1850.Google Scholar
Fitzgerald, KD, Stern, ER, Angstadt, M, et al. Altered function and connectivity of the medial frontal cortex in pediatric obsessive-compulsive disorder. Biol Psychiatry. 2010;68(11):1039–1047.Google Scholar
Remijnse, PL, Nielen, MM, van Balkom, AJ, et al. Differential frontal-striatal and paralimbic activity during reversal learning in major depressive disorder and obsessive-compulsive disorder. Psychol Med. 2009;39(9):1503–1518.Google Scholar
Nakao, T, Nakagawa, A, Nakatani, E, et al. Working memory dysfunction in obsessive-compulsive disorder: a neuropsychological and functional MRI study. J Psychiatr Res. 2009;43(8):784–791.Google Scholar
Woolley, J, Heyman, I, Brammer, M, Frampton, I, McGuire, PK, Rubia, K. Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control. Br J Psychiatry. 2008;192(1):25–31.Google Scholar
Chamberlain, SR, Menzies, L, Hampshire, A, et al. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science. 2008;321(5887):421–422.CrossRefGoogle ScholarPubMed
Gu, BM, Park, JY, Kang, DH, et al. Neural correlates of cognitive inflexibility during task-switching in obsessive-compulsive disorder. Brain. 2008;131(Pt 1):155–164.Google Scholar
Yücel, M, Harrison, BJ, Wood, SJ, et al. Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Arch Gen Psychiatry. 2007;64(8):946–955.Google Scholar
Roth, RM, Saykin, AJ, Flashman, LA, Pixley, HS, West, JD, Mamourian, AC. Event-related functional magnetic resonance imaging of response inhibition in obsessive-compulsive disorder. Biol Psychiatry. 2007;62(8):901–909.Google Scholar
Rauch, SL, Wright, CI, Savage, CR, et al. Brain activation during implicit sequence learning in individuals with trichotillomania. Psychiatry Res. 2007;154(3):233–240.CrossRefGoogle ScholarPubMed
Rauch, SL, Wedig, MM, Wright, CI, et al. Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder. Biol Psychiatry. 2007;61(3):330–336.CrossRefGoogle ScholarPubMed
Remijnse, PL, Nielen, MM, van Balkom, AJ, et al. Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch Gen Psychiatry. 2006;63(11):1125–1136.Google Scholar
Maltby, N, Tolin, DF, Worhunsky, P, O’Keefe, TM, Kiehl, KA. Dysfunctional action monitoring hyperactivates frontal-striatal circuits in obsessive-compulsive disorder: an event-related fMRI study. Neuroimage. 2005;24(2):495–503.Google Scholar
van den Heuvel, OA, Veltman, DJ, Groenewegen, HJ, et al. Frontal-striatal dysfunction during planning in obsessive-compulsive disorder. Arch Gen Psychiatry. 2005;62(3):301–309.CrossRefGoogle ScholarPubMed
Fitzgerald, KD, Welsh, RC, Gehring, WJ, et al. Error-related hyperactivity of the anterior cingulate cortex in obsessive-compulsive disorder. Biol Psychiatry. 2005;57(3):287–294.Google Scholar
Viard, A, Flament, MF, Artiges, E, et al. Cognitive control in childhood-onset obsessive-compulsive disorder: a functional MRI study. Psychol Med. 2005;35(7):1007–1017.Google Scholar
Ursu, S, Stenger, VA, Shear, MK, Jones, MR, Carter, CS. Overactive action monitoring in obsessive-compulsive disorder: evidence from functional magnetic resonance imaging. Psychol Sci. 2003;14(4):347–353.Google Scholar
Zhao, HZ, Wang, CH, Gao, ZZ, et al. Effectiveness of cognitive-coping therapy and alteration of resting-state brain function in obsessive-compulsive disorder. J Affect Disord. 2017;208:184–190.Google Scholar
Dunlop, K, Woodside, B, Olmsted, M, Colton, P, Giacobbe, P, Downar, J. Reductions in cortico-striatal hyperconnectivity accompany successful treatment of obsessive-compulsive disorder with dorsomedial prefrontal rTMS. Neuropsychopharmacology. 2016;41(5):1395–1403.Google Scholar
Yang, XY, Sun, J, Luo, J, et al. Regional homogeneity of spontaneous brain activity in adult patients with obsessive-compulsive disorder before and after cognitive behavioural therapy. J Affect Disord. 2015;188:243–251.Google Scholar
de Wit, SJ, van der Werf, YD, Mataix-Cols, D, et al. Emotion regulation before and after transcranial magnetic stimulation in obsessive compulsive disorder. Psychol Med. 2015;45(14):3059–3073.Google Scholar
Morgieve, M, N’Diaye, K, Haynes, WI, et al. Dynamics of psychotherapy-related cerebral haemodynamic changes in obsessive compulsive disorder using a personalized exposure task in functional magnetic resonance imaging. Psychol Med. 2014;44(7):1461–1473.Google Scholar
Shin, DJ, Jung, WH, He, Y, et al. The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder. Biol Psychiatry. 2014;75(8):606–614.Google Scholar
Figee, M, Luigjes, J, Smolders, R, et al. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat Neurosci. 2013;16(4):386–387.Google Scholar
Tolin, DF, Stevens, MC, Nave, A, Villavicencio, AL, Morrison, S. Neural mechanisms of cognitive behavioral therapy response in hoarding disorder: a pilot study. J Obsessive Compuls Relat Disord. 2012;1(3):180–188.Google Scholar
Han, JY, Kang, DH, Gu, BM, et al. Altered brain activation in ventral frontal-striatal regions following a 16-week pharmacotherapy in unmedicated obsessive-compulsive disorder. J Korean Med Sci. 2011;26(5):665–674.Google Scholar
Freyer, T, Kloppel, S, Tuscher, O, et al. Frontostriatal activation in patients with obsessive-compulsive disorder before and after cognitive behavioral therapy. Psychol Med. 2011;41(1):207–216.Google Scholar
Lázaro, L, Caldú, X, Junqué, C, et al. Cerebral activation in children and adolescents with obsessive-compulsive disorder before and after treatment: a functional MRI study. J Psychiatr Res. 2008;42(13):1051–1059.Google Scholar
Nabeyama, M, Nakagawa, A, Yoshiura, T, et al. Functional MRI study of brain activation alterations in patients with obsessive-compulsive disorder after symptom improvement. Psychiatry Res. 2008;163(3):236–247.Google Scholar
van der Wee, NJ, Ramsey, NF, van Megen, HJ, Denys, D, Westenberg, HG, Kahn, RS. Spatial working memory in obsessive-compulsive disorder improves with clinical response: a functional MRI study. Eur Neuropsychopharmacol. 2007;17(1):16–23.CrossRefGoogle ScholarPubMed
Nakao, T, Nakagawa, A, Yoshiura, T, et al. Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: a functional magnetic resonance imaging study. Biol Psychiatry. 2005;57(8):901–910.Google Scholar
Feusner, JD, Moody, T, Lai, TM, et al. Brain connectivity and prediction of relapse after cognitive-behavioral therapy in obsessive-compulsive disorder. Front Psychiatry. 2015;6:74.Google Scholar
Göttlich, M, Krämer, UM, Kordon, A, Hohagen, F, Zurowski, B. Resting-state connectivity of the amygdala predicts response to cognitive behavioral therapy in obsessive compulsive disorder. Biol Psychol. 2015;111:100–109.Google Scholar
Olatunji, BO, Ferreira-Garcia, R, Caseras, X, et al. Predicting response to cognitive behavioral therapy in contamination-based obsessive-compulsive disorder from functional magnetic resonance imaging. Psychol Med. 2014;44(10):2125–2137.Google Scholar
Sanematsu, H, Nakao, T, Yoshiura, T, et al. Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder: an fMRI study. J Psychiatr Res. 2010;44(4):193–200.Google Scholar
Jung, WH, Yücel, M, Yun, JY, et al. Altered functional network architecture in orbitofronto-striato-thalamic circuit of unmedicated patients with obsessive-compulsive disorder. Hum Brain Mapp. 2017;38(1):109–119.Google Scholar
Posner, J, Song, I, Lee, S, et al. Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder. Hum Brain Mapp. 2017;38(2):678–687.Google Scholar
Vaghi, MM, Vertes, PE, Kitzbichler, MG, et al. Specific frontostriatal circuits for impaired cognitive flexibility and goal-directed planning in obsessive-compulsive disorder: evidence from resting-state functional connectivity. Biol Psychiatry. 2017;81(8):708–717.Google Scholar
Armstrong, CC, Moody, TD, Feusner, JD, et al. Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder. J Affect Disord. 2016;193:175–184.Google Scholar
Chen, Y, Juhas, M, Greenshaw, AJ, et al. Abnormal resting-state functional connectivity of the left caudate nucleus in obsessive-compulsive disorder. Neurosci Lett. 2016;623:57–62.Google Scholar
Tang, W, Zhu, Q, Gong, X, Zhu, C, Wang, Y, Chen, S. Cortico-striato-thalamo-cortical circuit abnormalities in obsessive-compulsive disorder: a voxel-based morphometric and fMRI study of the whole brain. Behav Brain Res. 2016;313:17–22.Google Scholar
Tian, L, Meng, C, Jiang, Y, et al. Abnormal functional connectivity of brain network hubs associated with symptom severity in treatment-naive patients with obsessive-compulsive disorder: a resting-state functional MRI study. Prog Neuropsychopharmacol Biol Psychiatry. 2016;66:104–111.Google Scholar
Xie, C, Ma, L, Jiang, N, et al. Imbalanced functional link between reward circuits and the cognitive control system in patients with obsessive-compulsive disorder. Brain Imaging Behav. 2017;11(4):1099–1109.Google Scholar
Zhu, Y, Fan, Q, Zhang, H, et al. Altered intrinsic insular activity predicts symptom severity in unmedicated obsessive-compulsive disorder patients: a resting state functional magnetic resonance imaging study. BMC Psychiatry. 2016;16:104.Google Scholar
Bernstein, GA, Mueller, BA, Schreiner, MW, et al. Abnormal striatal resting-state functional connectivity in adolescents with obsessive-compulsive disorder. Psychiatry Res. 2016;247:49–56.Google Scholar
Abe, Y, Sakai, Y, Nishida, S, et al. Hyper-influence of the orbitofrontal cortex over the ventral striatum in obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2015;25(11):1898–1905.Google Scholar
Beucke, JC, Sepulcre, J, Eldaief, MC, Sebold, M, Kathmann, N, Kaufmann, C. Default mode network subsystem alterations in obsessive-compulsive disorder. Br J Psychiatry. 2014;205(5):376–382.Google Scholar
Hou, JM, Zhao, M, Zhang, W, et al. Resting-state functional connectivity abnormalities in patients with obsessive-compulsive disorder and their healthy first-degree relatives. J Psychiatry Neurosci. 2014;39(5):304–311.Google Scholar
Anticevic, A, Hu, S, Zhang, S, et al. Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biol Psychiatry. 2014;75(8):595–605.Google Scholar
Peng, ZW, Xu, T, He, QH, et al. Default network connectivity as a vulnerability marker for obsessive compulsive disorder. Psychol Med. 2014;44(7):1475–1484.Google Scholar
Gruner, P, Vo, A, Argyelan, M, et al. Independent component analysis of resting state activity in pediatric obsessive-compulsive disorder. Hum Brain Mapp. 2014;35(10):5306–5315.Google Scholar
Posner, J, Marsh, R, Maia, TV, Peterson, BS, Gruber, A, Simpson, HB. Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder. Hum Brain Mapp. 2014;35(6):2852–2860.Google Scholar
Weber, AM, Soreni, N, Noseworthy, MD. A preliminary study of functional connectivity of medication naive children with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;53:129–136.Google Scholar
Beucke, JC, Sepulcre, J, Talukdar, T, et al. Abnormally high degree connectivity of the orbitofrontal cortex in obsessive-compulsive disorder. JAMA Psychiatry. 2013;70(6):619–629.Google Scholar
Cheng, Y, Xu, J, Nie, B, et al. Abnormal resting-state activities and functional connectivities of the anterior and the posterior cortexes in medication-naive patients with obsessive-compulsive disorder. PLoS One. 2013;8(6):e67478.Google Scholar
Hou, J, Song, L, Zhang, W, et al. Morphologic and functional connectivity alterations of corticostriatal and default mode network in treatment-naive patients with obsessive-compulsive disorder. PLoS One. 2013;8(12):e83931.Google Scholar
Harrison, BJ, Pujol, J, Cardoner, N, et al. Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol Psychiatry. 2013;73(4):321–328.Google Scholar
Hou, J, Wu, W, Lin, Y, et al. Localization of cerebral functional deficits in patients with obsessive-compulsive disorder: a resting-state fMRI study. J Affect Disord. 2012;138(3):313–321.Google Scholar
Meunier, D, Ersche, KD, Craig, KJ, et al. Brain functional connectivity in stimulant drug dependence and obsessive-compulsive disorder. Neuroimage. 2012;59(2):1461–1468.Google Scholar
Stern, ER, Fitzgerald, KD, Welsh, RC, Abelson, JL, Taylor, SF. Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder. PLoS One. 2012;7(5):e36356.Google Scholar
Fitzgerald, KD, Welsh, RC, Stern, ER, et al. Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 2011;50(9):938–948.Google Scholar
Sakai, Y, Narumoto, J, Nishida, S, et al. Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder. Eur Psychiatry. 2011;26(7):463–469.Google Scholar
Zhang, T, Wang, J, Yang, Y, et al. Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder. J Psychiatry Neurosci. 2011;36(1):23–31.Google Scholar
Jang, JH, Kim, JH, Jung, WH, et al. Functional connectivity in fronto-subcortical circuitry during the resting state in obsessive-compulsive disorder. Neurosci Lett. 2010;474(3):158–162.Google Scholar
Harrison, BJ, Soriano-Mas, C, Pujol, J, et al. Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch Gen Psychiatry. 2009;66(11):1189–1200.Google Scholar
Saxena, S, Rauch, SL. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am. 2000;23(3):563–86Google Scholar
Phillips, ML, Young, AW, Senior, C, et al. A specific neural substrate for perceiving facial expressions of disgust. Nature. 1997;389(6550):495–498.Google Scholar
Sprengelmeyer, R, Rausch, M, Eysel, UT, Przuntek, H. Neural structures associated with recognition of facial expressions of basic emotions. Proc Biol Sci. 1998;265(1409):1927–1931.Google Scholar
Chamberlain, SR, Fineberg, NA, Blackwell, AD, Robbins, TW, Sahakian, BJ. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry. 2006;163(7):1282–1284.Google Scholar
Penadés, R, Catalán, R, Rubia, K, Andrés, S, Salamero, M, Gastó, C. Impaired response inhibition in obsessive compulsive disorder. Eur Psychiatry. 2007;22(6):404–410.Google Scholar
Menzies, L, Achard, S, Chamberlain, SR, et al. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain. 2007;130(Pt 12):3223–3236.Google Scholar
Chamberlain, SR, Fineberg, NA, Menzies, LA, et al. Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. Am J Psychiatry. 2007;164(2):335–338.Google Scholar
Veale, DM, Sahakian, BJ, Owen, AM, Marks, IM. Specific cognitive deficits in tests sensitive to frontal lobe dysfunction in obsessive-compulsive disorder. Psychol Med. 1996;26(6):1261–1269.Google Scholar
Dias, R, Robbins, TW, Roberts, AC. Dissociation in prefrontal cortex of affective and attentional shifts. Nature. 1996;380(6569):69–72.Google Scholar
Hornak, J, O’Doherty, J, Bramham, J, et al. Reward-related reversal learning after surgical excisions in orbito-frontal or dorsolateral prefrontal cortex in humans. J Cogn Neurosci. 2004;16(3):463–478.Google Scholar
Endrass, T, Schuermann, B, Kaufmann, C, Spielberg, R, Kniesche, R, Kathmann, N. Performance monitoring and error significance in patients with obsessive-compulsive disorder. Biol Psychol. 2010;84(2):257–263.Google Scholar
Johannes, S, Wieringa, BM, Nager, W, et al. Discrepant target detection and action monitoring in obsessive-compulsive disorder. Psychiatry Res. 2001;108(2):101–110.Google Scholar
Carrasco, M, Harbin, SM, Nienhuis, JK, Fitzgerald, KD, Gehring, WJ, Hanna, GL. Increased error-related brain activity in youth with obsessive-compulsive disorder and unaffected siblings. Depress Anxiety. 2013;30(1):39–46.Google Scholar
Purcell, R, Maruff, P, Kyrios, M, Pantelis, C. Neuropsychological deficits in obsessive-compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry. 1998;55(5):415–423.Google Scholar
Chamberlain, SR, Fineberg, NA, Blackwell, AD, Clark, L, Robbins, TW, Sahakian, BJ. A neuropsychological comparison of obsessive-compulsive disorder and trichotillomania. Neuropsychologia. 2007;45(4):654–662.Google Scholar
Kashyap, H, Kumar, JK, Kandavel, T, Reddy, YC. Neuropsychological functioning in obsessive-compulsive disorder: are executive functions the key deficit? Compr Psychiatry. 2013;54(5):533–540.Google Scholar
Delorme, R, Goussé, V, Roy, I, et al. Shared executive dysfunctions in unaffected relatives of patients with autism and obsessive-compulsive disorder. Eur Psychiatry. 2007;22(1):32–38.Google Scholar
van der Wee, NJ, Ramsey, NF, Jansma, JM, et al. Spatial working memory deficits in obsessive compulsive disorder are associated with excessive engagement of the medial frontal cortex. Neuroimage. 2003;20(4):2271–2280.Google Scholar
Rauch, SL, Whalen, PJ, Shin, LM, et al. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry. 2000;47(9):769–776.Google Scholar
Schneider, F, Weiss, U, Kessler, C, et al. Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol Psychiatry. 1999;45(7):863–871.Google Scholar
Stein, MB, Goldin, PR, Sareen, J, Zorrilla, LT, Brown, GG. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry. 2002;59(11):1027–1034.Google Scholar
Tillfors, M, Furmark, T, Marteinsdottir, I, et al. Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study. Am J Psychiatry. 2001;158(8):1220–1226.Google Scholar
Nitschke, JB, Sarinopoulos, I, Oathes, DJ, et al. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry. 2009;166(3):302–310.Google Scholar
McClure, EB, Monk, CS, Nelson, EE, et al. Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Arch Gen Psychiatry. 2007;64(1):97–106.Google Scholar
Quirk, GJ, Likhtik, E, Pelletier, JG, Paré, D. Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons. J Neurosci. 2003;23(25):8800–8807.Google Scholar
Sotres-Bayon, F, Cain, CK, LeDoux, JE. Brain mechanisms of fear extinction: historical perspectives on the contribution of prefrontal cortex. Biol Psychiatry. 2006;60(4):329–336.Google Scholar
Shin, LM, Wright, CI, Cannistraro, PA, et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry. 2005;62(3):273–281.Google Scholar
Williams, LM, Kemp, AH, Felmingham, K, et al. Trauma modulates amygdala and medial prefrontal responses to consciously attended fear. Neuroimage. 2006;29(2):347–357.Google Scholar
Britton, JC, Phan, KL, Taylor, SF, Fig, LM, Liberzon, I. Corticolimbic blood flow in posttraumatic stress disorder during script-driven imagery. Biol Psychiatry. 2005;57(8):832–840.Google Scholar
Lindauer, RJ, Booij, J, Habraken, JB, et al. Cerebral blood flow changes during script-driven imagery in police officers with posttraumatic stress disorder. Biol Psychiatry. 2004;56(11):853–861.CrossRefGoogle ScholarPubMed
Phan, KL, Britton, JC, Taylor, SF, Fig, LM, Liberzon, I. Corticolimbic blood flow during nontraumatic emotional processing in posttraumatic stress disorder. Arch Gen Psychiatry. 2006;63(2):184–192.Google Scholar
Peres, JF, Newberg, AB, Mercante, JP, et al. Cerebral blood flow changes during retrieval of traumatic memories before and after psychotherapy: a SPECT study. Psychol Med. 2007;37(10):1481–1491.Google Scholar
Seedat, S, Warwick, J, van Heerden, B, et al. Single photon emission computed tomography in posttraumatic stress disorder before and after treatment with a selective serotonin reuptake inhibitor. J Affect Disord. 2004;80(1):45–53.Google Scholar
Felmingham, K, Kemp, A, Williams, L, et al. Changes in anterior cingulate and amygdala after cognitive behavior therapy of posttraumatic stress disorder. Psychol Sci. 2007;18(2):127–129.Google Scholar
Simon, D, Kaufmann, C, Müsch, K, Kischkel, E, Kathmann, N. Fronto-striato-limbic hyperactivation in obsessive-compulsive disorder during individually tailored symptom provocation. Psychophysiology. 2010;47(4):728–738.Google Scholar
Upadhyay, J, Maleki, N, Potter, J, et al. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010;133(Pt 7):2098–2114.Google Scholar
Hu, Y, Salmeron, BJ, Gu, H, Stein, EA, Yang, Y. Impaired functional connectivity within and between frontostriatal circuits and its association with compulsive drug use and trait impulsivity in cocaine addiction. JAMA Psychiatry. 2015;72(6):584–592.Google Scholar
De Ridder, D, Vanneste, S, Kovacs, S, Sunaert, S, Dom, G. Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study. Neurosci Lett. 2011;496(1):5–10.Google Scholar
Valencia-Alfonso, CE, Luigjes, J, Smolders, R, et al. Effective deep brain stimulation in heroin addiction: a case report with complementary intracranial electroencephalogram. Biol Psychiatry. 2012;71(8):e35–e37.Google Scholar
Wrase, J, Schlagenhauf, F, Kienast, T, et al. Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage. 2007;35(2):787–794.Google Scholar
Bühler, M, Vollstädt-Klein, S, Kobiella, A, et al. Nicotine dependence is characterized by disordered reward processing in a network driving motivation. Biol Psychiatry. 2010;67(8):745–752.Google Scholar
Becker, A, Kirsch, M, Gerchen, MF, Kiefer, F, Kirsch, P. Striatal activation and frontostriatal connectivity during non-drug reward anticipation in alcohol dependence. Addict Biol. 2017;22(3):833–843.Google Scholar
Luijten, M, Schellekens, AF, Kühn, S, Machielse, MW, Sescousse, G. Disruption of reward processing in addiction: an image-based meta-analysis of functional magnetic resonance imaging studies. JAMA Psychiatry. 2017;74(4):387–398.Google Scholar
Martz, ME, Trucco, EM, Cope, LM, et al. Association of marijuana use with blunted nucleus accumbens response to reward anticipation. JAMA Psychiatry. 2016;73(8):838–844.Google Scholar
Reuter, J, Raedler, T, Rose, M, Hand, I, Gläscher, J, Büchel, C. Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat Neurosci. 2005;8(2):14708.Google Scholar
de Greck, M, Enzi, B, Prösch, U, Gantman, A, Tempelmann, C, Northoff, G. Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli. Hum Brain Mapp. 2010;31(11):1802–1812.Google Scholar
Balodis, IM, Kober, H, Worhunsky, PD, Stevens, MC, Pearlson, GD, Potenza, MN. Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biol Psychiatry. 2012;71(8):749–757.Google Scholar
Choi, JS, Shin, YC, Jung, WH, et al. Altered brain activity during reward anticipation in pathological gambling and obsessive-compulsive disorder. PLoS One. 2012;7(9):e45938.Google Scholar
Romanczuk-Seiferth, N, Koehler, S, Dreesen, C, Wüstenberg, T, Heinz, A. Pathological gambling and alcohol dependence: neural disturbances in reward and loss avoidance processing. Addict Biol. 2015;20(3):557–569.Google Scholar
Balodis, IM, Kober, H, Worhunsky, PD, et al. Monetary reward processing in obese individuals with and without binge eating disorder. Biol Psychiatry. 2013;73(9):877–886.Google Scholar
Cha, J, Ide, JS, Bowman, FD, Simpson, HB, Posner, J, Steinglass, JE. Abnormal reward circuitry in anorexia nervosa: a longitudinal, multimodal MRI study. Hum Brain Mapp. 2016;37(11):3835–3846.Google Scholar
de Ruiter, MB, Veltman, DJ, Goudriaan, AE, Oosterlaan, J, Sjoerds, Z, van den Brink, W. Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers. Neuropsychopharmacology. 2009;34(4):1027–1038.Google Scholar
Verdejo-Garcia, A, Clark, L, Verdejo-Román, J, et al. Neural substrates of cognitive flexibility in cocaine and gambling addictions. Br J Psychiatry. 2015;207(2):158–164.Google Scholar
Sato, Y, Saito, N, Utsumi, A, et al. Neural basis of impaired cognitive flexibility in patients with anorexia nervosa. PLoS One. 2013;8(5):e61108.Google Scholar
Saxena, S, Brody, AL, Maidment, KM, et al. Cerebral glucose metabolism in obsessive-compulsive hoarding. Am J Psychiatry. 2004;161(6):1038–1048.Google Scholar
Starcke, K, Tuschen-Caffier, B, Markowitsch, HJ, Brand, M. Dissociation of decisions in ambiguous and risky situations in obsessive-compulsive disorder. Psychiatry Res. 2010;175(1–2):114–120.Google Scholar
Erhan, C, Bulut, GÇ, Gökçe, S, et al. Disrupted latent decision processes in medication-free pediatric OCD patients. J Affect Disord. 2017;207:32–37.Google Scholar
Feusner, JD, Moody, T, Hembacher, E, et al. Abnormalities of visual processing and frontostriatal systems in body dysmorphic disorder. Arch Gen Psychiatry. 2010;67(2):197–205.Google Scholar
Li, W, Lai, TM, Bohon, C, et al. Anorexia nervosa and body dysmorphic disorder are associated with abnormalities in processing visual information. Psychol Med. 2015;45(10):2111–2122.Google Scholar
Rotge, JY, Guehl, D, Dilharreguy, B, et al. Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiatry Neurosci. 2008;33(5):405–412.Google ScholarPubMed
Baxter, LRJ, Schwartz, JM, Bergman, KS, et al. Caudate glucose metabolic rate changes with both drug and behavior therapy for obsessive-compulsive disorder. Arch Gen Psychiatry. 1992;49(9):681–689.Google Scholar
Benkelfat, C, Nordahl, TE, Semple, WE, King, AC, Murphy, DL, Cohen, RM. Local cerebral glucose metabolic rates in obsessive-compulsive disorder. Patients treated with clomipramine. Arch Gen Psychiatry. 1990;47(9):840–848.Google Scholar
Saxena, S, Brody, AL, Maidment, KM, et al. Localized orbitofrontal and subcortical metabolic changes and predictors of response to paroxetine treatment in obsessive-compulsive disorder. Neuropsychopharmacology. 1999;21(6):683–693.Google Scholar
Saxena, S, Brody, AL, Ho, ML, et al. Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression. Arch Gen Psychiatry. 2002;59(3):250–261.Google Scholar
Schwartz, JM, Stoessel, PW, Baxter, LRJ, Martin, KM, Phelps, ME. Systematic changes in cerebral glucose metabolic rate after successful behavior modification treatment of obsessive-compulsive disorder. Arch Gen Psychiatry. 1996;53(2):109–113.Google Scholar
Swedo, SE, Pietrini, P, Leonard, HL, et al. Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder. Revisualization during pharmacotherapy. Arch Gen Psychiatry. 1992;49(9):690–694.Google Scholar
Kang, DH, Kwon, JS, Kim, JJ, et al. Brain glucose metabolic changes associated with neuropsychological improvements after 4 months of treatment in patients with obsessive-compulsive disorder. Acta Psychiatr Scand. 2003;107(4):291–297.Google Scholar
Ho Pian, KL, van Megen, HJ, Ramsey, NF, et al. Decreased thalamic blood flow in obsessive-compulsive disorder patients responding to fluvoxamine. Psychiatry Res. 2005;138(2):89–97.Google Scholar
Rubin, RT, Ananth, J, Villanueva-Meyer, J, Trajmar, PG, Mena, I. Regional 133xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment. Biol Psychiatry. 1995;38(7):429–437.Google Scholar
Hoehn-Saric, R, Schlaepfer, TE, Greenberg, BD, McLeod, DR, Wong, SH. Cerebral blood flow in obsessive-compulsive patients with major depression: effect of treatment with sertraline or desipramine on treatment responders and non-responders. Psychiatry Res. 2001;108(2):89–100.Google Scholar
Brooks, SJ, Stein, DJ. A systematic review of the neural bases of psychotherapy for anxiety and related disorders. Dialogues Clin Neurosci. 2015;17(3):261–279.Google Scholar
Brody, AL, Saxena, S, Schwartz, JM, et al. FDG-PET predictors of response to behavioral therapy and pharmacotherapy in obsessive compulsive disorder. Psychiatry Res. 1998;84(1):1–6.Google Scholar

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