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Risperidone and pulmonary embolism: a harmful association? Case series and review of the literature

Published online by Cambridge University Press:  24 June 2014

Massimo Gallerani ,
Davide Imberti ,
Elisa Mari ,
Anna Marra  and
Roberto Manfredini
Massimo Gallerani*
Affiliation:
Internal Medicine, Az. Ospedaliera Universitaria “St. Anna”, Ferrara, Italy
Davide Imberti
Affiliation:
Internal Medicine, Az. Ospedaliera Universitaria “St. Anna”, Ferrara, Italy
Elisa Mari
Affiliation:
Internal Medicine, Az. Ospedaliera Universitaria “St. Anna”, Ferrara, Italy
Anna Marra
Affiliation:
Pharmaceutical Department, Az. Ospedaliera Universitaria “St. Anna”, Ferrara, Italy
Roberto Manfredini
Affiliation:
Department of Clinical and Experimental Medicine, Clinica Medica and Vascular Diseases Center, University of Ferrara, Ferrara, Italy
*
Massimo Gallerani, MD, Division of Internal Medicine, Department of Medicine, Az. Ospedaliera, Universitaria “St. Anna”, Corso Giovecca 203, I-44100 Ferrara, Italy. Tel: +39532236294; Fax: +39532236294; E-mail: m.gallerani@ospfe.it
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Extract

Gallerani M, Imberti D, Mari E, Marra A, Manfredini R. Risperidone and pulmonary embolism: a harmful association? Case series and review of the literature.

Objective: Risperidone is an atypical antipsychotic drug used to treat a number of psychiatric diseases, such as schizophrenia, schizoaffective and bipolar disorders and irritability in children with autism. Moreover, it is also often administered for short-term treatment of persistent aggression in people with moderate-to-severe Alzheimer's dementia. A possible association between risperidone and venous thromboembolism (VTE) has been described. We intended to verify the dimension of the problem in our hospital setting.

Methods: We considered all consecutive patients hospitalised in our Internal Medicine Department from January 2004 to December 2010, who were treated with risperidone and presented pulmonary embolism (PE).

Results: Four cases of patients, apparently free from the well-known major risk factors for VTE (i.e. cancer, prolonged immobilisation, acute cardiac and respiratory failure, infections), who presented PE associated with risperidone therapy, were reported in details.

Conclusions: A review of the available literature, discussing the possible different pathogenic reasons for this increased risk of VTE, is provided.

Keywords

psychosisrisperidonevenous thromboembolism
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 6 , December 2012 , pp. 361 - 368
Copyright
Copyright © Cambridge University Press 2012

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