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An unusual case of a solitary cardiac myofibroma causing severe right ventricular outflow tract obstruction in an infant

Published online by Cambridge University Press:  26 October 2020

Prashant K. Minocha Open the ORCID record for Prashant K. Minocha [Opens in a new window] ,
Fei Chen ,
Joseph J. Maleszewski ,
Achiau Ludomirsky ,
Ralph Mosca  and
T. K. Susheel Kumar
Prashant K. Minocha*
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, New York Grossman University School of Medicine, New York, USA Hassenfeld Children’s Hospital at NYU Langone, New York, USA
Fei Chen
Affiliation:
Department of Pathology, New York University Grossman School of Medicine, New York, USA
Joseph J. Maleszewski
Affiliation:
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
Achiau Ludomirsky
Affiliation:
Division of Pediatric Cardiology, Department of Pediatrics, New York Grossman University School of Medicine, New York, USA Hassenfeld Children’s Hospital at NYU Langone, New York, USA
Ralph Mosca
Affiliation:
Hassenfeld Children’s Hospital at NYU Langone, New York, USA Division of Pediatric Cardiothoracic Surgery, New York University Grossman School of Medicine, New York, USA
T. K. Susheel Kumar
Affiliation:
Hassenfeld Children’s Hospital at NYU Langone, New York, USA Division of Pediatric Cardiothoracic Surgery, New York University Grossman School of Medicine, New York, USA
*
Author for correspondence: Prashant K. Minocha, 401 East 34th Street, 4th Floor, Pediatric Cardiology, New York 10016, USA. Tel: +1 212 263 3079; Fax: +1 212 263 8301. E-mail: prashant.minocha@nyulangone.org
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Abstract

Cardiac tumours are relatively uncommon, particularly in children. Myofibroma is an extremely rare variety of cardiac tumour, which nearly always arises in the context of infantile myofibromatosis. Herein, we present a case of a solitary cardiac myofibroma causing right ventricular outflow tract obstruction in a 2-month-old male infant.

Keywords

Solitary myofibromacardiac tumourright ventricular outflow tract obstruction
Type
Brief Report
Information
Cardiology in the Young , Volume 31 , Issue 2 , February 2021 , pp. 297 - 299
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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References

Tzani, A, Doulamis, IP, Mylonas, KS, Avgerinos, D V, Nasioudis, D. Cardiac tumors in pediatric patients: a systematic review. World J Pediatr Congenit Hear Surg 2017; 8: 624–632.CrossRefGoogle ScholarPubMed
Nadas, A, Ellison, C. Cardiac tumors in infancy. Am J Cardiol 1968; 21: 363–366.CrossRefGoogle ScholarPubMed
Mashiah, J, Hadj-rabia, S, Dompmartin, A, et al. Infantile myofibromatosis: a series of 28 cases. J Am Acad Dermatol 2014; 72: 264–270.CrossRefGoogle Scholar
Ludomirsky, A, Vargo, TA, Murphy, DJ, Gresik, M V, Ott, DA, Mullins, CE. Intracardiac undifferentiated sarcoma in infancy. J Am Coll Cardiol 1985; 6: 1362–1364. doi: 10.1016/S0735-1097(85)80226-6 CrossRefGoogle ScholarPubMed
Oudijk, L, den Bakker, MA, Hop, WC, et al. Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases. Histopathology 2012; 60: E1–11.CrossRefGoogle ScholarPubMed
Sargar, K, Sheybani, E, Shenoy, A, Aranake-Chrisinger, J, Khanna, G. Pediatric fibroblastic and myofibroblastic tumors : a pictorial review. RadioGraphics 2016; 36: 1195–1214.CrossRefGoogle ScholarPubMed
Wu, SY, Mccavit, TL, Cederberg, K, Galindo, RL, Leavey, PJ. Chemotherapy for generalized infantile myofibromatosis with visceral involvement. J Pediatr Hematol Oncol 2015; 37: 4025.CrossRefGoogle ScholarPubMed
Antonescu, CR, Suurmeijer, AJ, Zhang, L, et al. Molecular characterization of inflammatory myofibroblastic tumors with frequent ALK and ROS1 gene fusions and rare novel RET rearrangement. Am J Surg Pathol 2015; 39: 957–967.CrossRefGoogle ScholarPubMed
Burke, A, Li, L, Kling, E, Kutys, R, Virmani, R, Miettinen, M. Cardiac inflammatory myofibroblastic tumor: a “benign” neoplasm that may result in syncope, myocardial infarction, and sudden death. Am J Surg Pathol 2007; 31: 1115–1122. doi: 10.1097/PAS.0b013e31802d68ff CrossRefGoogle ScholarPubMed