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Long-term outcome after atrioventricular valve surgery following modified Fontan operation

Published online by Cambridge University Press:  27 October 2010

Shaji C. Menon ,
Joseph A. Dearani  and
Frank Cetta
Shaji C. Menon*
Affiliation:
Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
Joseph A. Dearani
Affiliation:
Division of Cardiothoracic Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, United States of America
Frank Cetta
Affiliation:
Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America
*
Correspondence to: Dr S. C. Menon, MD, Pediatric Cardiology, 100 N. Mario Capechhi Drive, Salt Lake City, Utah 84113, United States of America. Tel: 801 662 5400; Fax: 801 662 5404; E-mail: shaji.menon@utah.edu
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Abstract

Objective

The objective of this study was to evaluate the early and late results of atrioventricular valve surgery after Fontan operation.

Background

Atrioventricular valve regurgitation is a known perioperative risk factor for Fontan operation. There are limited data on the outcomes of late atrioventricular valve surgery following Fontan operation.

Methods

Patients who underwent atrioventricular valve surgery following Fontan procedure were identified from the Mayo Clinic Fontan database. Medical records were reviewed for pre-operative, operative, and post-operative clinical and haemodynamic data. All patients not known to be deceased were sent health status questionnaires.

Results

A total of 61 patients (28 females) underwent atrioventricular valve surgery following Fontan procedure. The median age at atrioventricular valve surgery was 14 years. The median duration between Fontan and atrioventricular valve surgery was 4.7 years. Median follow-up was 9 years. There were a total of 32 (52%) deaths with 8 (13%) within 30 days of surgery. The 5-, 10-, and 15-year survival rates were 67%, 57%, and 45%, respectively. On follow-up, 44 of 61 (72%) had arrhythmias, 21 of 29 (72%) were symptomatic, and 12 of 61 (20%) developed protein-losing enteropathy. On multivariate analysis, reduced ventricular function and development of protein-losing enteropathy were associated with decreased survival.

Conclusion

Atrioventricular valve surgery after Fontan procedure is associated with substantial late morbidity and mortality. Atrioventricular valve surgery in this cohort of patients portends poor long-term outcome and is associated with a high incidence of protein-losing enteropathy. Reduced ventricular function and development of protein-losing enteropathy were associated with decreased survival.

Keywords

Atrioventricular valve surgeryFontan operationoutcome
Type
Original Articles
Information
Cardiology in the Young , Volume 21 , Issue 1 , February 2011 , pp. 83 - 88
Copyright
Copyright © Cambridge University Press 2010

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