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Usefulness and safety of anakinra in refractory Kawasaki disease complicated by coronary artery aneurysm

Published online by Cambridge University Press:  19 February 2018

Marie-Paule Guillaume ,
Héloïse Reumaux  and
François Dubos
Marie-Paule Guillaume*
Affiliation:
Pediatric Cardiology, CHU Lille and University of Lille, Lille, France
Héloïse Reumaux
Affiliation:
Pediatric Rheumatology Unit, CHU Lille and University of Lille, Lille, France Pediatric Emergency unit and Infectious Diseases, CHU Lille and University of Lille, Lille, France
François Dubos
Affiliation:
Pediatric Emergency unit and Infectious Diseases, CHU Lille and University of Lille, Lille, France
*
Author for correspondence: M.-P. Guillaume, Pediatric Cardiology, Institut Coeur-Poumon, University Hospital of Lille, France. Boulevard Prof J Leclercq, 59000 Lille, France. Tel: +33 3 20 44 69 49; Fax: + 33 3 20 44 54 56; E-mail: Marie-Paule.Guillaume@CHRU-Lille.fr
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Abstract

Kawasaki disease is an acute self-limited vasculitis of unknown aetiology. The prognosis depends mainly on coronary damage. There is no consensus regarding optimal adjunctive therapeutics for refractory forms to treatment by intravenous immunoglobulins and corticosteroids. We report the case of an 18-month-old infant with refractory Kawasaki disease complicated by diffuse aneurysms of coronary arteries and successfully treated by anakinra with partial regression of coronary aneurysms

Keywords

Refractory Kawasaki diseasecoronary aneurysmanakinrachildren
Type
Brief Report
Information
Cardiology in the Young , Volume 28 , Issue 5 , May 2018 , pp. 739 - 742
Copyright
© Cambridge University Press 2018 

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References

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