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Immunity to challenge in volunteers vaccinated with an inactivated current or earlier strain of influenza A(H3N2)

Published online by Cambridge University Press:  15 May 2009

H. E. Larson ,
D. A. J. Tyrrell ,
C. H. Bowker ,
C. W. potter  and
G. C. Schild
H. E. Larson
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
D. A. J. Tyrrell
Affiliation:
Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
C. H. Bowker
Affiliation:
Wellcome foundation Ltd, Ravens Lane, Brekhamsted, Herts HP4 2DY
C. W. potter
Affiliation:
Department of Virology, University of Sheffield Medical School, Beech Hill Road, Sheffield S10 2RX
G. C. Schild
Affiliation:
National Institute for Biological Standards and Control, Holly Hill, Hampstead, London NW3 6RB
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Summary

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Volunteers were inoculated with vaccine made from the 30c mutant, A/Port Chalmers/73 or B/Hong/8/73. Preliminary experiments showed that the 30c strain was antigenically quite close to A/HK/8/68. Volunteers given 30c developed haemagglutination inhibiting antibodies against the ‘current’ 1973 serotypes (as well as to the vaccine virus) but the titres were less than those after the A/PC/73 vaccine. Volunteers were then challenged with a live attenuated virus, WRL 105, with A/Finland/4/74 antigens, by intranasal inoculation. The rates of infection were 43% after B/Hong Kong/8/73, 20% after 30c and 5% after A/PC/73. This indicated that the 30c gave some protection but the vaccine prepared from the current strain gave more.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 2 , April 1978 , pp. 243 - 248
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Aymard-Henry, M., Coleman, M. T., Dowdle, W. R., Laver, W. G., Schild, G. C. & Webster, R. G. (1973). Influenzavirus neuraminidase and neuraminidase-inhibition test procedures. Bulletin of the World Health Organization 48, 199.Google ScholarPubMed
Fazekas De St Groth, S. & Hannoun, C. (1973). Selection by immunological presence of dominant mutants of influenza virus A/Hong Kong/68. Comptes Rendus Hebdomadaires des Séances de l'Académie des Sciences, Paris (Section D) 276, 1917.Google Scholar
Hannoun, C. (1973). Progress in influenza vaccination. 1) A vaccine against future strains. Nouvelle Presse Medicale 2, 1199.Google Scholar
Hobson, D., Curry, R. L., Beare, A. S. & Ward-Gardener, A. (1972). The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B virus. Journal of Hygiene 70, 767.Google Scholar
Hoskins, T. W., Davies, J. R., Allchin, A., Miller, C. L. & Pollock, T. M. (1973). Controlled trial of inactivated vaccine containing the A/Hong Kong strain during an outbreak of influenza due to the A/England/42/72 strain. Lancet ii, 116.CrossRefGoogle Scholar
Laver, W. G., Downie, J. C. & Webster, R. G. (1974). Studies on the antigenic variation in influenza virus. Evidence for multiple antigenic determinants on the haemagglutinin subunits of A/Hong Kong/68 and A/England/72 strains. Virology 59, 230.CrossRefGoogle Scholar
Lecomte, J. & Tyrrell, D. A. J. (1976). Isolation of anti-haemagglutinin antibodies with an influenza A virus immunoadsorbent. Journal of Immunological Methods 13, 355.CrossRefGoogle ScholarPubMed
Morris, C. A., Freestone, P. S., Stealey, V. M. & Oliver, P. R. (1975). Recombinant WRL 105 strain live attenuated influenza vaccine. Lancet ii, 196.CrossRefGoogle Scholar
Mostow, S. R., Schoenbaum, S. C., Dowdle, W. R., Coleman, M. T. & Kaye, H. S. (1969). Studies with inactivated influenza vaccines purified by zonal centrifugation. 1. Adverse reactions and serological responses. Bulletin of the World Health Organization 41, 525.Google ScholarPubMed
Schild, G. C., Oxford, J. S., Dowdle, W. R., Coleman, M., Pereira, M. S. & Chakra-Verty, P. (1974). Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic ‘drift’ for the Hong Kong virus. Bulletin of the World Health Organization 51, 1.Google ScholarPubMed
Stiver, H. G., Graves, P., Eickhoff, T. C. & Meiklejohn, G. (1973). Efficacy of ‘Hong Kong’ vaccine in preventing England variant influenza in 1972. New England Journal of Medicine 289, 1267.CrossRefGoogle ScholarPubMed
Stuart-Harris, C. H. & Schild, G. C. (1976). Influenza. The Viruses and the Disease. London, Arnold.Google Scholar
Tyrrell, D. A. J., Buckland, R., Rubenstein, D. & Sharpe, D. M. (1970). Vaccination against Hong Kong influenza in Britain. Journal of Hygiene 68, 359.CrossRefGoogle ScholarPubMed
Virelizier, J. L., Postlethwaite, R., Schild, G. C. & Allison, A. C. (1974). Antibody responses to antigenic determinants of influenza virus haemagglutinin. 1. Thymus dependence of antibody formation and thymus independence of immunological memory. Journal of Experimental Medicine 140, 1559.CrossRefGoogle ScholarPubMed
Westwood, M., Woodward, P. M. & Perkins, F. T. (1971). The British reference preparation for influenza virus haemagglutinin. Journal of Hygiene 69, 263.CrossRefGoogle ScholarPubMed