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Prophylaxis against tetanus in non-immune patients with wounds: the role of antibiotics and of human antitetanus globulin

Published online by Cambridge University Press:  15 May 2009

E. J. L. Lowbury ,
A. Kidson ,
H. A. Lilly ,
M. D. Wilkins  and
P. M. Jackson
E. J. L. Lowbury
Affiliation:
M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital
A. Kidson
Affiliation:
M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital
H. A. Lilly
Affiliation:
M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital
M. D. Wilkins
Affiliation:
M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital
P. M. Jackson
Affiliation:
M.R.C. Industrial Injuries and Burns Research Unit, Birmingham Accident Hospital
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The potential value of oral erythromycin for antitetanus prophylaxis in non-immune patients with open wounds was assessed. Serum obtained by venepuncture from healthy persons 2 h after an oral dose of an erythromycin preparation was used as a culture medium rendered anaerobic by addition of cooked meat. Strains of Clostridium tetani inoculated into these sera failed to multiply when the donor had taken 500 mg of erythromycin estolate before a meal; other erythromycin preparations and the estolate at a dosage of 250 mg were ineffective or inconsistent in their inhibition of the growth of Cl. tetani.

Human antitetanus globulin (ATG) was given to 12 patients, 9 with severe injuries and 3 with extensive burns, all of whom were judged, from their history, to be non-immune (or with expired immunity); all except one had received large intravenous infusions of blood and/or other fluids. Serum antitoxin assays by a mouse protection technique on days 0, 1–2, 3–5, 6–10 and 14 + showed no detectable antitoxin (< 0·01) unit/ml) in the initial (pre-ATG) sample from three patients with severe injuries and in one with extensive burns. All the patients in the severely injured group showed an early appearance or increase in tetanus antitoxin to protective titres. Two of the three severely burned patients showed, respectively, delayed appearance or an increase in antitoxin; the other burned patients showed a reduction from the initial pre-ATG titre, followed by a return to that titre after day 5.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 2 , April 1978 , pp. 267 - 274
Copyright
Copyright © Cambridge University Press 1978

References

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