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Single radial haemolysis: a survey of antibody titres in the Highland Region of Scotland to recent strains of Influenza A

Published online by Cambridge University Press:  15 May 2009

A. W. L. Joss ,
J. K. McPherson  and
H. Williams
A. W. L. Joss
Affiliation:
Microbiology Laboratories, Raigmore Hospital, Inverness
J. K. McPherson
Affiliation:
Microbiology Laboratories, Raigmore Hospital, Inverness
H. Williams
Affiliation:
Microbiology Laboratories, Raigmore Hospital, Inverness
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Summary

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The single radial haemolysis test is conveniently practical and economical and promises to have wide applicability in the study of influenza antibodies in human populations. It can also be adapted for preliminary examination of new virus isolates during epidemics.

Using this test a rather higher proportion of the population in the Highland Region of Scotland was found to possess antibody to a recent epidemic strain of influenza (A/Scotland/74) than was the case in the south of England. Antibody was detected and apparently evenly spread throughout all but the most remote island communities. Some evidence of the spread of the subsequent variant, A/Victoria/75, was obtained. Most of the school children in our study had high antibody titres to recent strains but the proportion with high antibody titres to these strains declined speedily from the age of 17 years onwards.

Type
Research Article
Information
Journal of Hygiene , Volume 80 , Issue 1 , February 1978 , pp. 1 - 11
Copyright
Copyright © Cambridge University Press 1978

References

REFERENCES

Bradstreet, C. M. P. & Taylor, C. E. D. (1962). Technique of complement-fixation test applicable to the diagnosis of virus diseases. Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service 21, 96–104.Google Scholar
Buchan, K. A. & Reid, D. (1972). Epidemiological aspects of influenza in Lewis. Health Bulletin 30, 183–6.Google ScholarPubMed
Carey, D. E., Dunn, F. L., Robinson, R. Q., Jensen, K. E. & Martin, J. D. (1958). Community-wide epidemic of Asian-strain influenza – clinical and subclinical illnesses among schoolchildren. Journal of the American Medical Association 167, 1459–63.CrossRefGoogle Scholar
Chin, T. D. Y., Foley, J. F., Doto, I. L., Gravelle, C. R. & Weston, J. (1960). Morbidity and mortality characteristics of Asian strain influenza. Public Health Reports (Washington) 75, 149–58.CrossRefGoogle ScholarPubMed
Dunn, F. L., Carey, D. E., Cohen, A. & Martin, J. D. (1959). Epidemiologic studies of Asian influenza in a Louisiana parish. American Journal of Hygiene 70, 351–71.Google Scholar
Fazekas de St Groth, S. & Webster, R. G. (1966). Disquisitions on original antigenic sin. 1. Evidence in man. Journal of Experimental Medicine 124, 331–45.CrossRefGoogle ScholarPubMed
Hennessy, A. V., Davenport, F. M., Horton, R. J. M., Napier, J. A. & Francis, T. Jr (1964). Asian influenza: occurrence and recurrence, a community and family study. Military Medicine 129, 38–50.CrossRefGoogle ScholarPubMed
Hobson, D., Curry, R. L., Beare, A. S. & Ward-Gardner, A. (1973). The role of serum haemagglutination inhibiting antibody in protection against challenge infection with influenza A2 and B viruses. Journal of Hygiene 70, 767–77.Google Scholar
Moffet, H. L., Cramblett, H. G. & Dobbins, J. (1964). Outbreak of influenza A2 among immunised children. Journal of the American Medical Association 190, 806–10.Google Scholar
Pereira, H. G., Pereira, M. S. & Law, V. G. (1964). Antigenic variants of influenza A2 virus. Bulletin of the World Health Organization 31, 129–32.Google ScholarPubMed
Pereira, M. S. (1975). Influenza A antibody levels in the UK – 1975. Communicable Disease Report 47/75.Google Scholar
Russell, S. M., McCahon, D. & Beare, A. S. (1975). A single radial haemolysis technique for the measurement of influenza antibody. Journal of General Virology 27, 1–10.CrossRefGoogle ScholarPubMed
Schild, G. C., Pereira, M. S. & Chakraverty, P. (1975). Single radial haemolysis: a new method for the assay of antibody to influenza haemagglutinin. Bulletin of the World Health Organization 52, 43–50.Google ScholarPubMed
Smith, A. J. & Davies, J. R. (1976). Natural infection with influenza A (H3N2). The development, persistence and effect of antibodies to the surface antigens. Journal of Hygiene 77, 271–82.CrossRefGoogle Scholar
Smith, J. W. G. (1975). Influenza, 1974–75. Communicable Disease Report 5/75.Google Scholar