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2340 – The Role Of Age And Gender In Predicting Serum Levels Of Il-6 And Tnf-α In Patients With Schizophrenia And Major Depression

Published online by Cambridge University Press:  15 April 2020

M. Pantovic ,
B. Dunjic-Kostic ,
N. Radonjic ,
V. Vukovic ,
A. Damjanovic ,
M. Jasovic-Gasic ,
N. Petronijevic  and
M. Ivkovic
M. Pantovic
Affiliation:
Department for Affective Disorders, Clinic of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia
B. Dunjic-Kostic
Affiliation:
Department for Affective Disorders, Clinic of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia
N. Radonjic
Affiliation:
Institute of Clinical and Medical Biochemistry, Belgrade, Serbia School of Medicine, University of Belgrade, Belgrade, Serbia
V. Vukovic
Affiliation:
Department for Affective Disorders, Clinic of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia
A. Damjanovic
Affiliation:
Department for Affective Disorders, Clinic of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia School of Medicine, University of Belgrade, Belgrade, Serbia
M. Jasovic-Gasic
Affiliation:
School of Medicine, University of Belgrade, Belgrade, Serbia
N. Petronijevic
Affiliation:
Institute of Clinical and Medical Biochemistry, Belgrade, Serbia School of Medicine, University of Belgrade, Belgrade, Serbia
M. Ivkovic
Affiliation:
Department for Affective Disorders, Clinic of Psychiatry, Clinical Center of Serbia, Belgrade, Serbia School of Medicine, University of Belgrade, Belgrade, Serbia

Abstract

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Introduction

Growing evidence in the field of psychoneuroimmunology indicates an interconnection between psychiatric disorders, in particular schizophrenia and mood disorders, and cytokine alternations. Gender and aging are commonly reported to affect cytokine levels, but contrasting conclusions still represent a topic for debate.

Objectives and aims

Our aim was to investigate the role of age and gender in the serum levels of Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-α), in patients with schizophrenia (SCH) and major depression (MDD).

Method

We measured serum levels of IL-6 and TNF-α in acute exacerbation of illness, in 37 patients with MDD, and compared them to 43 patients with SCH. The serum levels were measured by the enzyme-linked immunosorbent assay (ELISA). All patients fulfilled the ICD-10 criteria.

Results

The significant interaction between gender and psychiatric disorders on serum cytokine levels, and the association between IL-6 and TNF-α and age, in both groups of patients, were not detected. However, when applied the linear regression model with the serum cytokine levels as dependant variable, and age, gender, and psychiatric disorder as independent variables, the significant predictive effect of age on levels of both investigated cytokines was detected. The patients over 35 years of age had higher levels of IL-6 and even significantly lower levels of TNF-α, regardless of the diagnosis.

Conclusion

The results suggest that the aging process could be a relevant factor influencing the immune status of patients with SCH and MDD. Further prospective studies are essential to further investigate biological mechanisms that underlie these multidimensional interconnections.

Type
Abstract
Information
European Psychiatry , Volume 28 , Issue S1: Abstracts of the 21th European Congress of Psychiatry , 2013 , 28-E1470
Copyright
Copyright © European Psychiatric Association 2012
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