In our previous study, we demonstrated that in young healthy lean women consumption of High Energy Nutritional Supplement drinks (HENSD) enhances daily energy intake and therefore promotes positive energy balance(Reference Fatima, Gerasimidis, Tsiountsioura, Arvanitdou, Wright and Malkova1). Previous evidence suggests that acute changes in energy balance may modify fasting and postprandial concentrations of triglycerides (TAG), glucose and insulin(Reference Smith, Magkos, Reeds, Okunade, Patterson and Mittendorfer2, Reference Bellou, Maraki, Magkos, Botonaki, Panagiotakos and Kavouras3). This study aims to find out that whether consumption of HENSD in the evening for five days has a detrimental impact on plasma lipids, glycaemia and insulinaemia.
Twenty-three healthy females with a mean (SD) age of 25(5) years participated in a single blind randomised controlled, crossover study. Participants consumed HENSD (594 kcal) or PLACEBO (91kcal) for five days in the evening. Participants were asked to record their dietary intake during days of supplementation. On the sixth day plasma lipids, insulin and glucose concentrations were measured in the fasted state and at 30, 60, 90 and120 minutes after ad libitum buffet breakfast and lunch.
Averaged daily energy (HENSD, 9·2(0·3) MJ; PLACEBO, 8·2(0·4) MJ, P = 0·03), carbohydrate (HENSD, 286 (11) g; PLACEBO, 249 (13) g, P = 0·03) and fat (HENSD, 91·1(6) g; PLACEBO, 70·8 (4) g, P = 0·007) intake were significantly higher in HENSD trial. Data on fasting and postprandial concentration of plasma insulin, glucose, lipids and HOMA(IR) are presented in table below.
Values are presented as mean ± SE (n = 11).*Significantly different (P < 0·05) from HENSD. Postprandial concentrations are presented as AUCs (time-averaged areas under concentrations vs. time curve).
In conclusion, short-term supplementation with HENSD can be expected to reduce insulin sensitivity but have no impact on fasting lipids and postprandial lipemia, insulinaemia and glycaemia.
