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Optimum nutrition: thiamin, biotin and pantothenate

Published online by Cambridge University Press:  28 February 2007

David A. Bender
David A. Bender*
Affiliation:
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK
*
Corresponding author: Dr David Bender, fax +44 (0)171 380 7193, email dab@biochem.ucl.ac.uk
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Abstract

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The metabolism of glucose is deranged in thiamin deficiency, but once any deficiency has been corrected there is no further effect of increased thiamin intake on the ability to metabolize glucose through either pyruvate dehydrogenase (EC 1.2.4.1) and the citric acid cycle, or the pentose phosphate pathway, in which transketolase (EC 2.2.1.1) is the thiamin-dependent step. It has been suggested that the Wernicke-Korsakoff syndrome is associated with a genetic variant of transketolase which requires a higher than normal concentration of thiamin diphosphate for activity. This finding would suggest that there may be a group of the population who have a higher than average requirement for thiamin, but the evidence is not convincing. There are no estimates of biotin requirements, but either coenzyme saturation of erythrocyte pyruvate carboxylase, or the excretion of 3-hydroxy-isovalerate (perhaps after a test dose of leucine) could be used to assess requirements in depletion–repletion studies. Biotin deficiency leads to impaired glucose tolerance, but it is unlikely that glucose tolerance could be used to assess optimum biotin status, since other more common factors affect glucose tolerance to a greater extent. Plasma triacylglycerol and non-esterified fatty acids are moderately elevated in pantothenic acid deficiency. However, this is unlikely to be useful in assessing pantothenate status, since again, other more common factors affect plasma lipids. To date there are no biochemical indices of adequate pantothenate nutrition, and no estimates of requirements.

Keywords

Thiamin statusBiotin statusPantothenate statusTransketolase activationErythrocyte pyruvate carboxylase3-Hydroxy-isovalerate excretion
Type
‘Optimal nutrition’
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 2 , May 1999 , pp. 427 - 433
Copyright
Copyright © The Nutrition Society 1999

References

Bannister, DW (1976) The biochemistry of fatty liver and kidney syndrome: biotin-mediated restoration of hepatic gluconeogenesis in vitro and its relationship to pyruvate carboxylase activity. Biochemical Journal 156, 167–173.CrossRefGoogle ScholarPubMed
Barshop, BA, Yoshida, I, Ajami, A, Sweetman, L, Wolff, JA, Sweetman, FR, Prodanos, C, Smith, M & Nyhan, WL (1991) Metabolism of 1-[13C]propionate in vivo in patients with disorders of propionate metabolism. Pediatric Research 30, 15–22.CrossRefGoogle Scholar
Berthon, HA, Kuchel, PW & Nixon, PF (1992) High control coefficient of transketolase in the nonoxidative pentose phosphate pathway of human erythrocytes: NMR, antibody and computer simulation studies. Biochemistry 31, 12792–12798.CrossRefGoogle ScholarPubMed
Bettendorf, L, Hennuy, B, De Clerck, A & Wins, P (1994) Chloride permeability of rat brain membrane vesicles correlates with thiamine triphosphate content. Brain Research 652, 157–170.CrossRefGoogle Scholar
Bettendorf, L, Kolb, HA & Schoffeniels, E (1993 a) Thiamine triphosphate activates an anion channel of large unit conductance in neuroblastoma cells. Journal of Membrane Biology 136, 281–288.CrossRefGoogle Scholar
Bettendorf, L, Peeters, M, Wins, P & Schoffeniels, E (1993 b) Metabolism of thiamine triphosphate in rat brain: correlation with chloride permeability. Journal of Neurochemistry 60, 423–434.CrossRefGoogle Scholar
Bitsch, R, Tôth-Dersi, A & Hoetzel, D (1985) Biotin deficiency and biotin supply. Annals of the New York Academy of Sciences 447, 133–139.CrossRefGoogle ScholarPubMed
Blansjaar, BA, Zwang, R & Blijnberg, BG (1991) No transketolase abnormalities in Wernicke-Korsakoff patients. Journal of Neurological Science 106, 88–90.CrossRefGoogle ScholarPubMed
Blass, JP & Gibson, GE (1977) Abnormality of a thiamine-requiring enzyme in patients with Wernicke-Korsakoff syndrome. New England Journal of Medicine 297, 1367–1370.CrossRefGoogle ScholarPubMed
Blass, JP, Sheu, KF, Cooper, AJ, Jung, EH & Gibson, GE (1992) Thiamin and Alzheimer's disease. Journal of Nutritional Science and Vitaminology Special issue, 400–401.Google ScholarPubMed
Butterworth, RF, Kril, JJ & Harper, CG (1993) Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome. Alcoholism: Clinical and Experimental Research 17, 1084–1088.CrossRefGoogle Scholar
Calingasan, NY, Gandy, SE, Baker, H, Sheu, KF, Smith, JD, Lamb, BT, Gearhart, JD, Buxbaum, JD, Harper, C, Selkoe, DJ, Proe, DL, Sisodia, SS & Gibson, CE (1996) Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein immunoreactivity in brain regions damaged by thiamine deficiency. American Journal of Pathology 149, 1063–1071.Google ScholarPubMed
Chauhan, J & Dakshinamurti, K (1991) Transcriptional regulation of the glucokinase gene by biotin in starved rats. Journal of Biological Chemistry 266, 10035–10038.CrossRefGoogle ScholarPubMed
Coy, JF, Dubel, S, Kioschis, P, Thomas, K, Micklem, G, Delius, H & Poustka, A (1996) Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. Genomics 32, 309–316.CrossRefGoogle ScholarPubMed
Donaldson, WE (1985) Biotin effects on fatty acid synthesis in chicks. Annals of the New York Academy of Sciences 447, 105–111.CrossRefGoogle ScholarPubMed
Froguel, P, Zouali, H, Vionnet, N, Velho, G, Vaxillaire, M, Sun, F, Lesage, S, Stoffel, M, Takeda, J & Passa, P (1993) Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. New England Journal of Medicine 328, 697–702.CrossRefGoogle ScholarPubMed
Harper, C (1979) Wernicke's encephalopathy, a more common disease than realised (a neuropathological study of 51 cases). Journal of Neurology, Neurosurgery and Psychiatry 42, 226–231.CrossRefGoogle ScholarPubMed
Héroux, M, Raghavendra-Rao, VL, Lavoie, J, Richardson, JS & Butterworth, RF (1996) Alteration of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease. Metabolic Brain Disease 11, 81–88.CrossRefGoogle ScholarPubMed
Horwitt, MK & Kreisler, O (1949) The determination of early thiamine deficient states by estimation of blood lactate and pyruvate after glucose administration and exercise. Journal of Nutrition 37, 411–427.CrossRefGoogle ScholarPubMed
Hymes, J, Fleischhauer, K & Wolf, B (1995) Biotinylation of histones by human serum biotinidase: assessment of biotinyl-transferase activity in sera from normal individuals and children with biotinidase deficiency. Biochemical and Molecular Medicine 56, 76–83.CrossRefGoogle ScholarPubMed
Hymes, J & Wolf, B (1996) Biotinidase and its roles in biotin metabolism. Clinica Chimica Acta 255, 1–11.CrossRefGoogle ScholarPubMed
Jeyasingham, MD, Pratt, OE, Burns, A, Shaw, GK, Thomson, AD & Marsh, A (1987) The activation of red blood cell transketolase in groups of patients especially at risk from thiamin deficiency. Psychological Medicine 17, 311–318.CrossRefGoogle ScholarPubMed
Johnson, AR, Hood, RL & Emery, JL (1980) Biotin and the sudden infant death syndrome. Nature 285, 159–160.CrossRefGoogle ScholarPubMed
Kirschbaum, N, Clemons, R, Marino, KA, Sheedy, G, Nguyen, ML & Smith, CM (1990) Pantothenate kinase activity in livers of genetically diabetic mice (db/db) and hormonally treated cultured rat hepatocytes. Journal of Nutrition 120, 1376–1386.CrossRefGoogle ScholarPubMed
Kopinski, JS, Leibholz, J, Bryden, WL & Fogarty, AC (1989) Biotin studies in pigs. 1. Biotin deficiency in the young pig. British Journal of Nutrition 62, 751–759.CrossRefGoogle ScholarPubMed
Krause, KH, Bonjour, JP, Berlit, P & Kochen, W (1985) Biotin status of epileptics. Annals of the New York Academy of Sciences 447, 297–313.CrossRefGoogle ScholarPubMed
McCool, BA, Plonk, SG, Martin, PR & Singleton, CK (1993) Cloning of human transketolase cDNAs and comparison of the nucleotide sequence of the coding region in Wernicke-Korsakoff and non-Wernicke-Korsakoff individuals. Journal of Biological Chemistry 268, 1397–1404.CrossRefGoogle ScholarPubMed
Martin, PR, McCool, BA & Singleton, CK (1995) Molecular genetics of transketolase in the pathogenesis of the Wernicke-Korsakoff syndrome. Metabolic Brain Disease 10, 45–55.CrossRefGoogle ScholarPubMed
Mastrogiacoma, F, Bergeron, C & Kish, SJ (1993) Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease. Journal of Neurochemistry 61, 2007–2114.CrossRefGoogle Scholar
Mastrogiacoma, F, Bettendorf, L, Grisar, T & Kish, SJ (1996) Brain thiamine, its phosphate esters and its metabolizing enzymes in Alzheimer's disease. Annals of Neurology 39, 585–591.CrossRefGoogle ScholarPubMed
Matschinsky, F, Liang, Y, Kesavan, P, Wang, L, Froguel, P, Velho, G, Cohen, D, Permutt, MA, Tanizawa, Y & Jetton, TL (1993) Glucokinase as pancreatic beta cell glucose sensor and diabetes gene. Journal of Clinical Investigation 92, 2092–2098.CrossRefGoogle ScholarPubMed
Matsumoto, M, Kuhara, T, Inoue, Y, Shinka, T & Matsumoto, I (1991) Abnormal fatty acid metabolism in patients in hopantenate therapy during clinical episodes. Journal of Chromatography 562, 139–145.CrossRefGoogle ScholarPubMed
Matsumoto, T, Hardy, RW & Stickney, RR (1994) Pantothenate deficiency detection in rainbow trout (Oncorhynchus mykiss). Journal of Nutrition 124, 430–435.CrossRefGoogle Scholar
Meador, K, Loring, D, Nichols, M, Zamrini, E, Rivner, M, Posas, H, Thompson, E & Moore, E (1993) Preliminary findings of high dose thiamine in dementia of Alzheimer's type. Journal of Geriatric Psychiatry and Neurology 6, 222–229.CrossRefGoogle ScholarPubMed
Mimori, Y, Katsuoka, H & Nakamura, S (1996) Thiamine therapy in Alzheimer's disease. Metabolic Brain Disease 11, 89–94.CrossRefGoogle ScholarPubMed
Mock, DM (1991) Skin manifestations of biotin deficiency. Seminars in Dermatology 10, 296–302.Google ScholarPubMed
Mock, DM, Johnson, SB & Holman, RT (1988) Effects of biotin deficiency on serum fatty acid composition: evidence for abnormalities in humans. Journal of Nutrition 118, 342–348.CrossRefGoogle ScholarPubMed
Mock, NI, Malik, MI, Stumbo, PJ, Bishop, WP & Mock, DM (1997) Increased urinary excretion of 3-hydroxyisovalerate and decreased urinary excretion of biotin are sensitive early indicators of decreased biotin status in experimental biotin deficiency. American Journal of Clinical Nutrition 65, 951–958.CrossRefGoogle Scholar
Mock, NI & Mock, DM (1992) Biotin deficiency in rats: disturbances of leucine metabolism are detectable early. Journal of Nutrition 122, 1493–1499.CrossRefGoogle ScholarPubMed
Mukherjee, AB, Svoronos, S, Ghazanfari, A, Martin, PR, Fisher, A, Roecklein, B, Rodbard, D, Staton, R, Behar, D & Berg, CJ (1987) Transketolase abnormality in cultured fibroblasts from familial chronic alcoholic men and their male offspring. Journal of Clinical Investigation 79, 1039–1043.CrossRefGoogle ScholarPubMed
Nakahiro, M, Fujita, N, Fukuchi, I, Saito, K, Nishimura, T & Yoshida, H (1985) Pantoyl-γ-aminobutyrate facilitates cholinergic function in the central nervous system. Journal of Pharmacology and Experimental Therapeutics 232, 501–506.Google ScholarPubMed
Nixon, PF, Kaczmarek, MJ, Tate, J, Kerr, RA & Price, J (1984) An erythrocyte transketolase isoenzyme pattern associated with the Wernicke-Korsakoff syndrome. European Journal of Clinical Investigation 14, 278–281.CrossRefGoogle ScholarPubMed
Noda, S, Haratake, J, Sasaki, A, Ishii, N, Umezaki, H & Horie, A (1991) Acute encephalopathy with hepatic steatosis induced by pantothenate antagonist, calcium hopantenate, in dogs. Liver 11, 134–142.CrossRefGoogle ScholarPubMed
Nolan, KA, Black, RS, Sheu, KF, Langberg, J & Blass, JP (1991) A trial of thiamine in Alzheimer's disease. Archives of Neurology 8, 81–83.CrossRefGoogle Scholar
Nyhan, WL (1987) Inborn errors of biotin metabolism. Archives of Dermatology 123, 1696a–1698a.CrossRefGoogle ScholarPubMed
Page, MG, Ankoma-Sey, V, Coulson, WF & Bender, DA (1989) Brain glutamate and γ-aminobutyrate (GABA) metabolism in thiamin-deficient rats. British Journal of Nutrition 62, 245–253.CrossRefGoogle ScholarPubMed
Pietrzik, K, Hesse, C & Hötzel, D (1975) Influencing of acetylation and corticosterone biosynthesis through long-term pantothenate deficiency in rats. International Journal of Vitamin and Nutrition Research 45, 251–261.Google ScholarPubMed
Proud, VK, Rizzo, WB, Patterson, JW, Heard, GS & Wolf, B (1990) Fatty acid alterations and carboxylase deficiencies in the skin of biotin-deficient rats. American Journal of Clinical Nutrition 51, 853–858.CrossRefGoogle ScholarPubMed
Reed, LJ (1976) Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation and dephosphorylation. In Thiamine, pp. 19–30 [Gubler, GC, Fujiwara, M and Dreyfus, PM, editors]. New York: Wiley.Google Scholar
Reibel, DK, Wyse, BW, Berkich, DA & Neely, JR (1982) Coenzyme A metabolism in pantothenate deficient rats. Journal of Nutrition 112, 1144–1150.CrossRefGoogle ScholarPubMed
Scriver, R, MacKenzie, S, Chow, CL & Delvin, E (1971) Thiamine-responsive maple-syrup-urine disease. Lancet i, 310–312.CrossRefGoogle Scholar
Smith, CM, Narrow, CM, Kendrick, ZV & Steffen, C (1987) The effect of pantothenate deficiency in mice on their metabolic response to fast and exercise. Metabolism 36, 115–121.CrossRefGoogle ScholarPubMed
Stryer, L (1995) Biochemistry, 4th ed. New York: W. H. Freeman & Co.Google Scholar
Thornber, EJ, Dunlop, RH & Gawthorne, JM (1980) Thiamin deficiency in the lamb: changes in thiamin phosphate esters in the brain. Journal of Neurochemistry 35, 713–717.CrossRefGoogle ScholarPubMed
Thurnham, DI (1981) Red cell enzyme tests of vitamin status: do marginal deficiencies have any physiological significance? Proceedings of the Nutrition Society 40, 155–163.CrossRefGoogle ScholarPubMed
Vas, A, Gachalyi, B & Kaldor, A (1990) Pantothenic acid, acute ethanol consumption and sulphadimidine acetylation. International Journal of Pharmacology, Therapeutics and Toxicology 28, 111–114.Google ScholarPubMed
Volpe, JJ & Vagelos, PR (1973) Fatty acid synthetase of mammalian brain, liver and adipose tissue: regulation by prosthetic group turnover. Biochimica et Biophysica Acta 326, 293–304.CrossRefGoogle ScholarPubMed
Wang, JJ, Martin, PR & Singleton, CK (1997) A transketolase assembly defect in a Wernicke-Korsakoff syndrome patient. Alcoholism: Clinical and Experimental Research 21, 576–580.CrossRefGoogle Scholar
Watanabe, T, Dakshinamurti, K & Persaud, TV (1995) Biotin influences palatal development of mouse embryos in organ culture. Journal of Nutrition 125, 2114–2121.CrossRefGoogle ScholarPubMed
Watanabe, T & Endo, A (1984) Teratogenic effects of avidin-induced biotin deficiency in mice. Teratology 30, 91–94.CrossRefGoogle ScholarPubMed
Watkins, BA (1988) Influences of biotin deficiency and dietary trans-fatty acids on tissue lipids in chickens. British Journal of Nutrition 61, 99–111.CrossRefGoogle Scholar
Webster, MJ, Scheett, TP, Doyle, MR & Branz, M (1997) The effect of a thiamin derivative on exercise performance. European Journal of Applied Physiology 75, 520–524.Google ScholarPubMed
Wittwer, CT, Beck, S, Peterson, M, Davidson, R, Wilson, DE & Hansen, RG (1990) Mild pantothenate deficiency in rats elevates serum triglyceride and free fatty acid levels. Journal of Nutrition 120, 719–725.CrossRefGoogle ScholarPubMed
Zhang, H, Osada, K, Sone, H & Furukawa, Y (1997) Biotin administration improves impaired glucose tolerance of streptozotocin-induced diabetic Wistar rats. Journal of Nutritional Science and Vitaminology 43, 271–280.CrossRefGoogle ScholarPubMed
Zubaran, C, Fernandes, JG & Rodnight, R (1997) Wernicke-Korsakoff syndrome. Postgraduate Medical Journal 73, 27–31.CrossRefGoogle ScholarPubMed