Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-28T06:33:14.926Z Has data issue: false hasContentIssue false

Wasting illness as a disorder of body weight regulation

Published online by Cambridge University Press:  28 February 2007

Michael W. Schwartz
Affiliation:
Departments of Medicine, University of Washington, Harborview Medical Center and VA Puget Sound Health Care System, Seattle, WA 98108, USA
Randy J. Seeley
Affiliation:
Department of Psychology, University of Washington, Harborview Medical Center and VA Puget Sound Health Care System, Seattle, WA 98108, USA
Stephen C. Woods
Affiliation:
Department of Psychology, University of Washington, Harborview Medical Center and VA Puget Sound Health Care System, Seattle, WA 98108, USA
Rights & Permissions [Opens in a new window]

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Symposium on ‘New perspectives in the anorexia-cachexia syndrome’
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Ahima, R. S., Prabakaran, D., Mantzoros, C., Qu, D., Lowell, B., Maratos-Flier, E. & Flier, J. (1996). Role of leptin in the neuroendocrine response to fasting. Nature 382, 250252.CrossRefGoogle ScholarPubMed
Bagdade, J. D., Bierman, E. L. & Porte, D. Jr (1967). The significance of basal insulin levels in the evaluation of the insulin response to glucose in diabetic and nondiabetic subjects. Journal of Clinical Investigation 46, 15491557.CrossRefGoogle ScholarPubMed
Brady, L. S., Smith, M. A., Gold, P. W. & Herkenham, M. (1990). Altered expression of hypothalamic neuropeptide mRNAs in food restricted and food-deprived rats. Neuroendocrinology 52, 441447.CrossRefGoogle ScholarPubMed
Bray, G. A., Fisler, J. & York, D. A. (1990). Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Frontiers in Neuroendocrinology 11, 128181.Google Scholar
Campfield, L. A., Smith, F. J., Gulsez, Y., Devos, R. & Burn, P. (1995). Mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546549.CrossRefGoogle ScholarPubMed
Chua, S. C., Chung, W. K., Wu-Peng, X. S., Zhang, Y., Liu, S., Tartaglia, L. & Leibel, R. L. (1996). Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (Leptin) receptor. Science 271, 994996.CrossRefGoogle ScholarPubMed
Clark, J. T., Kalra, P. S., Crowley, W. R. & Kalra, S. P. (1984). Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115, 427429.CrossRefGoogle ScholarPubMed
Coleman, D. L. (1973). Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 9, 294298.CrossRefGoogle ScholarPubMed
Considine, R. V., Sinha, M. K., Heiman, M. L., Kriaucinas, A., Stephens, T. W., Nyce, M. R., Ohannesian, J. P., Marco, C. C., McKee, L. J., Bauer, T. L. & Caro, J. F. (1996). Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334, 292295.CrossRefGoogle ScholarPubMed
Drenick, E. J. & Johnson, D. (1978). Weight reduction by fasting and semistarvation in morbid obesity: long-term follow-up. International Journal of Obesity 2, 123132.Google ScholarPubMed
Frederich, R. C., Lollmann, B., Hamann, A., Napolitano-Rosen, A., Kahn, B. B., Lowell, B. B. & Flier, J. S. (1995). Expression of OB mRNA and its encoded protein in rodents. Journal of Clinical Investigation 96, 16581663.CrossRefGoogle Scholar
Garner, D. M. & Wooley, S. C. (1991). Confronting the failure of behavioral and dietary treatments for obesity. Clinical Psychology Reviews 11, 729780.CrossRefGoogle Scholar
Ghilardi, N., Ziegler, S., Wiestner, A., Stoffel, R. M. H. & Skoda, R. C. (1996). Defective STAT signaling by the leptin receptor in diabetic mice. Proceedings of the National Academy of Sciences USA 93, 62316235.CrossRefGoogle ScholarPubMed
Grunfeld, C. & Feingold, K. (1992). Metabolic disturbances and wasting in the acquired immunodeficiency syndrome. New Engiand Journal of Medicine 327, 329337.Google ScholarPubMed
Grunfeld, C., Pang, M., Shigenaga, J., Jensen, P., Lallone, R., Friedman, J. & Feingold, K. (1996). Serum leptin levels in the acquired immunodeficiency syndrome. Journal of Clinical Endocrinology and Metabolism 81, 43424346.Google ScholarPubMed
Halaas, J. L., Gajiwala, K. S., Maffel, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K. & Friedman, J. M. (1995). Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543546.CrossRefGoogle ScholarPubMed
Hellerstein, M. K., Meydani, S. N., Meydani, M., Wu, K. & Dinarello, C. A. (1989). Interleukin-1-Induced anorexia in the rat. Journal of Clinical Investigation 84, 228235.CrossRefGoogle ScholarPubMed
Kaiyala, K. J., Woods, S. C. & Schwartz, M. W. (1995). A new model for the regulation of energy balance by the central nervous system. American Journal of Clinical Nutrition 62, 1123S1134S.CrossRefGoogle ScholarPubMed
Keesey, R. E. & Powley, T. L. (1986). The regulation of body weight. Annual Review of Psychology 37, 109133.CrossRefGoogle ScholarPubMed
Kennedy, G. C. (1953). The role of depot fat in the hypothalamic control of food intake in the rat. Proceedings of the Royal Society of London 140B, 579592.Google Scholar
Krahn, D. D. & Gosnell, B. A. (1988). Behavioural effects of corticotrophin-releasing factor: localization and characterization of central effects. Brain Research 443, 6369.CrossRefGoogle ScholarPubMed
Lee, G., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I. & Friedman, J. M. (1996). Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632635.CrossRefGoogle ScholarPubMed
Leibel, R. L., Rosenbaum, M. & Hirsch, J. (1995). Changes in energy expenditure resulting from altered body weight. New England Journal of Medicine 332, 621628.CrossRefGoogle ScholarPubMed
Mercer, J. G., Hoggard, N., Williams, L., Lawrence, C. B., Hannah, L. T. & Trayhurn, P. (1996). Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEES Letters 387, 113116.CrossRefGoogle Scholar
O'Donohue, T. L., Chronwall, B. M., Pruss, R. M., Mezey, E., Kiss, J. Z., Eiden, L. E., Massari, V. J., Tessel, R. E., Pickel, V. M., DiMaggio, D. A., Hotchkiss, A. J., Crowley, W. R. & Zukowska-Grojec, Z. (1985). Neuropeptide Y and peptide YY neuronal and endocrine systems. Peptides 6, 755768.CrossRefGoogle ScholarPubMed
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T. & Collins, F. (1995). Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269, 540543.CrossRefGoogle ScholarPubMed
Plata-Salaman, C. R. (1991). Immunoregulators in the nervous system. Neuroscience and Biobehavioral Reviews 15, 185215.CrossRefGoogle ScholarPubMed
Rosenbaum, M., Nicholson, M., Hirsch, J., Heymsfield, S. B., Gallagher, D., Chu, F. & Leibel, R. L. (1996). Effects of gender, body composition, and menopause on plasma concentrations of leptin. Journal of Clinical Endocrinology and Metabolism 81, 34243427.Google ScholarPubMed
Rothwell, N. (1989). Central effects of CRF on metabolism and energy balance. Neuroscience and Biobehaviorul Reviews 14, 263271.CrossRefGoogle Scholar
Sahu, A., Kalra, P. S. & Kalra, S. P. (1988). Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides 9, 8386.CrossRefGoogle ScholarPubMed
Sapolsky, R., Rivier, C., Yamamoto, G., lotsky, P. & Vale, W. (1987). Interleukin-1 stimulates the secretion of hypothalamic corticotrophin-releasing factor. Science 238, 522526.CrossRefGoogle Scholar
Schwartz, M. W., Dallman, M. F. & Woods, S. C. (1995). The hypothalamic response to starvation: implications for the study of wasting disorders. American Journal of Physiology 269, R949R957.Google Scholar
Schwartz, M. W., Figlewicz, D. P., Baskin, D. G., Woods, S. C. & Porte, D. Jr (1992 a). Insulin in the brain: a hormonal regulator of energy balance. Endocrinology Reviews 13, 387414.Google Scholar
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Bum, P. & Baskin, D. G. (1996). Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation 98, 11011106.CrossRefGoogle ScholarPubMed
Schwartz, M. W., Sipols, A. J., Grubin, C. E. & Baskin, D. G. (1993). Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin and glutamic acid decarboxyle. Brain Research Bulletin 31, 361367.CrossRefGoogle Scholar
Schwartz, M. W., Sipols, A. J., Marks, J. L., Sanacora, G., White, J. D., Scheurinck, A., Kahn, S. E., Baskin, D. G., Woods, S. C., Figlewicz, D. P. & Porte, D. Jr (1992 b). Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130, 36083616.CrossRefGoogle ScholarPubMed
Sipols, A. J., Baskin, D. G. & Schwartz, M. W. (1995). Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44, 147151.CrossRefGoogle ScholarPubMed
Stanley, B. G. (1993). Neuropeptide Y in multiple hypothalamic sites controls eating behavior, endocrine, and autonomic systems for energy balance. In The Biology of Neuropeptide Y and Related Peptides, pp. 457509 [Colmers, W. F. and Wahlestedt, C., editors]. Totowa, NJ: Humana Press.Google Scholar
Stanley, B. G., Kyrkouli, S. E., Lampert, S. & Leibowitz, S. F. (1986). Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity. Peptides 7, 11891192.CrossRefGoogle ScholarPubMed
Suemaru, S., Hashimoto, K., Hattori, T., Inoue, H., Kageyama, J. & Ota, Z. (1986). Starvation-induced changes in rat brain corticotrophin-releasing factor (CRF) and pituitary-adrenocortical response. Life Sciences 39, 11611166.CrossRefGoogle ScholarPubMed
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., Muir, C., Sanker, S., Moriarty, A., Moore, K. J., Smutko, J. S., Mays, G. G., Woolf, E. A., Monroe, C. A. & Tepper, R. I. (1995). Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 12631271.CrossRefGoogle ScholarPubMed
White, J. D. & Kershaw, M. (1989). Increased hypothalamic neuropeptide Y expression following food deprivation. Molecular and Cellular Neuroscience 1, 4148.CrossRefGoogle Scholar
Woods, S. C., Porte, D. J., Bobbioni, E., Ionescu, E., Sauter, J. F., Rohner-Jeanrenaud, F., & Jeanrenaud, B. (1985). Insulin: its relationship to the central nervous system and to the control of food intake and body weight. American Journal of Clinical Nutriton 42, 10631071.CrossRefGoogle Scholar
Zarjevski, N., Cusin, I., Vetter, R., Rohner-Jeanrenaud, F., & Jeanrenaud, B. (1993). Chronic intracerebro-ventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133, 17531758.CrossRefGoogle Scholar
Zhang, Y., Proenca, R., Maffie, M., Barone, M., Leopold, L. & Friedman, J. M. (1994). Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425432.CrossRefGoogle ScholarPubMed