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1 results

  • Soyabean glyceollins: biological effects and relevance to human health

  • Hyo Jung Kim, Ji-Sun Lim, Woo-Keun Kim, Jong-Sang Kim
  • Journal:
    Proceedings of the Nutrition Society / Volume 71 / Issue 1 / February 2012
    Published online by Cambridge University Press:
    07 November 2011, pp. 166-174
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  • Glyceollins, one family of phytoalexins, are de novo synthesised from daidzein in the soyabean upon exposure to some types of fungus. The efficiency of glyceollin production appears to be influenced by soyabean variety, fungal species, and the degree of physical damage to the soyabean. The compounds have been shown to have strong antioxidant and anti-inflammatory activities, and to inhibit the proliferation and migration of human aortic smooth muscle cells, suggesting their potential to prevent atherosclerosis. It has also been reported that glyceollins have inhibited the growth of prostate and breast cancer cells in xenograft animal models, which is probably due to their anti-oestrogenic activity. In essence, glyceollins deserve further animal and clinical studies to confirm their health benefits.