For two given projections p and q in a C*-algebra, we investigate how to express the Drazin inverses of the product pq and the difference p−q, and give applications. As a special case, we obtain the results of [C. Y. Deng, ‘The Drazin inverses of products and differences of orthogonal projections’, J. Math. Anal. Appl.335 (2007) 64–71], with considerably simpler proofs.