The antidote R-25788 (N,N-diallyl-2,2-dichloroacetamide) protected corn (Zea mays L. ‘DeKalb 315A’) seedlings from injury caused by the acetanilide herbicides, alachlor [2-chloro-2′,6′-diethyl-N-(methoxymethyl)acetanilide], metolachlor [2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-methoxy-1-methylethyl)acetamide], H-22234 [N-chloroacetyl-N-(2,6-diethylphenyl)glycine ethyl ester], and H-26910 [N-chloroacetyl-N-(2-methyl-6-ethylphenyl)glycine isopropyl ester] in a greenhouse study. R-25788, however, did not protect four weed species tested. R-25788 only partially protected corn from injury caused by acetochlor [2-chloro-N-(ethoxymethyl)-6′-ethyl-o-acetotoluidide]. R-25788 was an effective antidote whether applied preemergence, preplant-incorporated, or as a tank mix. Injury symptoms caused by EPTC (S-ethyl dipropylthiocarbamate) and the acetanilide herbicides were similar; both caused leaf twisting and rolling, and at high rates leaves failed to emerge through the coleoptile.