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1 results

Toxicity of lofepramine and fluvoxamine in heart disease
Colm Cooney, Mark Barber
Journal:

Irish Journal of Psychological Medicine / Volume 11 / Issue 4 / December 1994

Published online by Cambridge University Press:

13 June 2014, pp. 164-165

Print publication:

December 1994
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Therapeutic doses of lofepramine and fluvoxamine were associated with the development of first degree and second degree heart block, respectively, in an 83 year old man with a normal ECG prior to treatment and with no history of cardiovascular disease. Caution is recommended in treating patients with newer generation antidepressants, even in cases where cardiac status appears normal prior to treatment.

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Toxicity of lofepramine and fluvoxamine in heart disease