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Toxicity of lofepramine and fluvoxamine in heart disease

Published online by Cambridge University Press:  13 June 2014

Colm Cooney  and
Mark Barber
Mark Barber
Affiliation:
Department of Old Age Psychiatry, John Connolly Wing, St. Bernard's Hospital, Southall, Middlesex UB1 3EU, England
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Abstract

Therapeutic doses of lofepramine and fluvoxamine were associated with the development of first degree and second degree heart block, respectively, in an 83 year old man with a normal ECG prior to treatment and with no history of cardiovascular disease. Caution is recommended in treating patients with newer generation antidepressants, even in cases where cardiac status appears normal prior to treatment.

Keywords

LofepramineFluvoxamineHeart block
Type
Brief Reports
Information
Irish Journal of Psychological Medicine , Volume 11 , Issue 4 , December 1994 , pp. 164 - 165
Copyright
Copyright © Cambridge University Press 1994

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