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2 results

  • Changes on myocardial perfusion scintigraphy and contrast-enhanced cardiac magnetic resonance imaging after definitive radiotherapy in patients with lung cancer

  • A. Lideståhl, T. Larsson, L. Thorén, O. Brodin, P. A. Lind
  • Journal:
    Journal of Radiotherapy in Practice / Volume 21 / Issue 4 / December 2022
    Published online by Cambridge University Press:
    10 March 2021, pp. 455-461
  • Aim:

    To determine whether myocardial perfusion scintigraphy (MPS) changes in lung cancer patients treated with radiotherapy (RT) were detectable with late gadolinium enhancement cardiac magnetic resonance imaging (LGE CMR).

    Materials and methods:

    Twenty-one patients with lung cancer were evaluated pre-RT and at 2 and 6 months post-RT follow-up (FU) with MPS and LGE CMR. MPS changes in the left ventricle (LV) were analysed using the semi-quantitative summed rest score method (20 segments) and the Bull’s-eye-view technique. The LGE CMR studies were analysed for visual signs of myocardial damage (fibrosis), that is, focal LGE in the LV and cardiac function parameters.

    Results:

    MPS changes were detected in 7/20 patients at 2 months FU and in 8/13 patients at 6 months FU. Only one patient had a new irreversible defect judged to be caused by direct irradiation. MPS changes in two cases were deemed to be caused by attenuation. All new MPS defects were minor and no corresponding myocardial damage, or any functional changes, were evident on LGE CMR.

    Findings:

    The extent of MPS changes at 6 months FU appeared less prominent than in previous reports. No visual signs or functional changes corresponding to myocardial damage were detected on LGE CMR. A risk for false-positive MPS changes caused by attenuation is evident.

  • Abnormalities in myocardial perfusion after surgical correction of pulmonary atresia with intact ventricular septum

  • Britt-Marie Ekman-Joelsson, Håkan Berggren, Ann-Britt Boll, Rune Sixt, Jan Sunnegårdh
  • Journal:
    Cardiology in the Young / Volume 18 / Issue 1 / February 2008
    Published online by Cambridge University Press:
    15 January 2008, pp. 89-95

  • We describe the results of myocardial perfusion scintigraphy performed 4 to 15 years after surgery in 12 patients with pulmonary atresia and intact ventricular septum. We used single photon emission computed tomography after injection of technetium Tc-99m tetrofosmin at submaximal exercise test. The patients, 7 girls and 5 boys, with a mean age of 11 years, and a range from 6 to 19 years, had either undergone biventricular repair, in 5 cases, or univentricular palliation in the remaining 7. This second group included 4 patients with ventriculo-coronary arterial communications. Of the children, 3 with biventricular repair and 6 with univentricular palliation had perfusion defects. Children with biventricular repair had perfusion defects in the ventricular septum, while those having univentricular palliation also had defects located to the left ventricular free wall. All children with ventriculo-coronary arterial communications had perfusion defects both in the ventricular septum and in the left ventricular free wall.