A patent ductus arteriosus in patients with transposition of the great arteries is usually beneficial to allow shunting between pulmonary and systemic circulations. However, if the duct is too large, it can cause haemodynamic instability, pulmonary oedema and compromised organ perfusion. We present a neonate in whom a 5 mm short and tubular ductus arteriosus was causing significant cardiac failure with necrotising enterocolitis and liver impairment, leaving him too unstable for the arterial switch operation. At day 14 of life (3.1 kg), the baby underwent successful transcatheter closure using an Amplatzer vascular plug (Abbott, Chicago, Il, USA) delivered through a 5Fr catheter from the aortic side. The procedure was uncomplicated and successful as the neonate was extubated 2 days later. He subsequently underwent successful arterial switch surgery.

This study addresses the challenges faced by Modern Foreign Language teacher trainees when asked to investigate the potential of a Personal Digital Assistant to support them both in their learning and in their teaching during their training year. Personal Digital Assistants (PDAs) such as the Windows Pocket PCs used in this study have previously been found supportive by trainees in other professions with a large information content. Modern Foreign Languages (MFL) was chosen as the subject for this investigation as a particularly wide range of potential opportunities specific to MFL was foreseen. These opportunities ranged from supporting student teachers' learning by enabling access to email and other internet resources wherever they were based to enabling ‘on the spot’ audio or video recordingto support their teaching. For this investigation, seven student teachers from an MFL initial teacher training programme were loaned PDAs for the duration of their course. This paper reports on interviews conducted at the end of the training year with six of the student teachers in order to elicit their views on the PDAs they were loaned. They were all experienced information technology users and willing to explore the devices but there had always seemed to be a preferred alternative technology available either at home or in the classroom. Their reports shed much light on the current climate in schools and subject culture pressures as interpreted by student teachers in MFL departments but told us only a little about the functionality of a PDA and how it can support mobile assisted language learning. The socio-cultural context within the MFL departments where the trainees were placed meant that they did not feel comfortable about exploring the PDA functionality. They were not yet confident in their pedagogical identities and mostly felt they could not disrupt the established practice with the novel technology. However, when the devices were used, applications that appeared most effective in supporting learning to teach MFL with PDAs were those that enabled the capture of on-the-spot events and reflections. This could be either through the inbuilt recording functions, especially video, or by making notes using either the on-screen keyboard or by handwriting recognition.

The a-wave of the human dark-adapted ERG is thought to derive from activity of rod photoreceptors. However, other sources within the retina could potentially perturb this simple equation. We investigated the extent to which the short-latency dark-adapted rod a-wave of the primate ERG is dominated by the rod photoresponse and the applicability of the phototransduction model to fit the rod a-wave. Dark-adapted Ganzfeld ERGs were elicited over a 5-log-unit intensity range using short bright xenon flashes, and the light-adapted cone responses were subtracted to isolate the rod ERG a-wave. Intravitreal 4-phosphono-butyric acid (APB) and cis-2,3-piperidine-dicarboxylic acid (PDA) were applied to isolate the photoreceptor response. The Hood and Birch version of the phototransduction model, Rmax[1 − e−I·S·(t−teff)2] , was fitted to the a-wave data while allowing Rmax and S to vary. Three principle observations were made: (1) At flash intensities ≥0.77 log sc-td-s the leading edge of the normalized rod ERG a-wave tracks the isolated photoreceptor response across the first 20 ms or up to the point of b-wave intrusion. The rod ERG a-wave was essentially identical to the isolated receptor response for all intensities that produce peak responses within 14 ms after the flash. (2) The best fit of sensitivity (S) was not affected by APB and/or PDA, suggesting that the inner retina contributes very little to the dark-adapted a-wave. (3) APB always reduced the maximum dark-adapted a-wave amplitude (by 15–30%), and PDA always increased it (by 7–15%). Using the phototransduction model, both events can be interpreted as a scaling of the photoreceptor dark current. This suggests that activity of postreceptor cells somehow influences the rod dark current, possibly by feedback through horizontal cells (although currently not demonstrated for the rod system), or by altering the ionic concentrations near the photoreceptors, or by neuromodulator effects mediated by dopamine or melatonin.