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2 results

  • The Positive Predictive Value of Onconeural Antibody Testing: A Retrospective Review

  • Adrian Budhram, Michael W. Nicolle, Liju Yang
  • Journal:
    Canadian Journal of Neurological Sciences / Volume 45 / Issue 5 / September 2018
    Published online by Cambridge University Press:
    03 August 2018, pp. 577-579
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  • Paraneoplastic syndromes (PNS) are immune-mediated neurologic diseases that occur as an indirect effect of malignancy, and can be challenging to diagnose. Onconeural antibodies have a greater than 95% association with cancer, and their presence in a patient with neurologic symptoms is reportedly highly indicative of PNS. However, we performed a single-centre retrospective review to determine the positive predictive value of onconeural antibody testing, and found it to be concerningly low (39%). Recognising the limitations of onconeural antibody testing is critical to ensure accurate test interpretation, avoid unnecessary repeated malignancy screening and prevent the use of potentially hazardous immunotherapy.