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  • 5 - Wrangling the Matrix: Lessons from the RDoC Working Memory Domain

  • from Section 2
  • Edited by Kenneth S. Kendler, Virginia Commonwealth University, Josef Parnas, University of Copenhagen, Peter Zachar, Auburn University, Montgomery
  • Book:
    Levels of Analysis in Psychopathology
    Published online:
    02 April 2020
    Print publication:
    02 April 2020, pp 59-77

  • Summary

    This chapter describes the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) initiative, illustrating how elements from different “levels” or “units” of analysis are represented as domains, constructs, and subconstructs to form the RDoC “matrix.” The example of “working memory” is used to show that the matrix possesses conceptual elements drawn from diverse theories and experiments about working memory, but lacks a controlled vocabulary and specification of putative relations among the elements, that would serve as an organizing framework. An ontology (in the informatics sense) can be developed using existing tools to represent and analyze relations between most adjacent levels, with a notable exception: the link between cellular/network systems and observable behavior, which directly confronts the mind-body problem. Finally, the chapter considers how the field may best wrangle with the RDoC matrix using bottom-up and top-down strategies, while leveraging advantages and avoiding pitfalls of computational models and artificial intelligence.