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5 - Wrangling the Matrix: Lessons from the RDoC Working Memory Domain

from Section 2

Published online by Cambridge University Press:  02 April 2020

By
Robert M. Bilder
Edited by
Kenneth S. Kendler ,
Josef Parnas  and
Peter Zachar
Kenneth S. Kendler
Affiliation:
Virginia Commonwealth University
Josef Parnas
Affiliation:
University of Copenhagen
Peter Zachar
Affiliation:
Auburn University, Montgomery
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Summary

This chapter describes the National Institute of Mental Health (NIMH) Research Domain Criteria (RDoC) initiative, illustrating how elements from different “levels” or “units” of analysis are represented as domains, constructs, and subconstructs to form the RDoC “matrix.” The example of “working memory” is used to show that the matrix possesses conceptual elements drawn from diverse theories and experiments about working memory, but lacks a controlled vocabulary and specification of putative relations among the elements, that would serve as an organizing framework. An ontology (in the informatics sense) can be developed using existing tools to represent and analyze relations between most adjacent levels, with a notable exception: the link between cellular/network systems and observable behavior, which directly confronts the mind-body problem. Finally, the chapter considers how the field may best wrangle with the RDoC matrix using bottom-up and top-down strategies, while leveraging advantages and avoiding pitfalls of computational models and artificial intelligence.

Keywords

Research Domains Criteria Initiative (RDoC)working memorycognitionneurosciencemental disordersneural circuitsinformaticscausalitymind-body problemontology
Type
Chapter
Information
Levels of Analysis in Psychopathology
Cross-Disciplinary Perspectives
 , pp. 59 - 77
Publisher: Cambridge University Press
Print publication year: 2020

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