Given a minimal action $\alpha $ of a countable group on the Cantor set, we show that the alternating full group $\mathsf {A}(\alpha )$ is non-amenable if and only if the topological full group $\mathsf {F}(\alpha )$ is $C^*$ -simple. This implies, for instance, that the Elek–Monod example of non-amenable topological full group coming from a Cantor minimal $\mathbb {Z}^2$ -system is $C^*$ -simple.