In this paper we consider a two-phase model describing the growth of avascular solid tumors when taking into account the effects of cell-to-cell adhesion and taxis due to nutrient. The tumor is surrounded by healthy tissue which is the source of nutrient for tumor cells. In a three-dimensional context, we prove that the mathematical formulation corresponds to a well-posed problem, and find radially symmetric steady-state solutions of the problem. They appear in the regime where the rate of cell apoptosis to cell proliferation is less than the far field nutrient concentration. Furthermore, we study the stability properties of those radially symmetric equilibria and find, depending on the biophysical parameters involved in the problem, both stable and unstable regimes for tumor growth.

A mathematical model of infiltrative tumour growth is investigated taking into account transitions between two possible states of malignant cells: proliferation and migration. These transitions are considered to depend on oxygen level in a threshold manner where high oxygen concentration allows cell proliferation, while concentration below a certain critical value induces cell migration. The infiltrative tumour spreading rate dependence on model parameters is obtained. It is shown that the tumour growth rate depends on the tissue oxygen level in a threshold manner.

A model of tumor growth in a spatial environment is analyzed. The model includesproliferating and quiescent compartments of tumor cells indexed by successively mutated cell phenotypesof increasingly proliferative aggressiveness. The model incorporates spatial dependencedue to both random motility and directed movement haptotaxis. The model structures tumor cellsby both cell age and cell size. The model consists of a system of nonlinear partial differentialequations for the compartments of tumor cells, extracellular matrix, matrix degradative enzyme,and oxygen. The existence, uniqueness, positivity, regularity, and growth characteristics of thesolutions are investigated.

Normal and abnormal cells are positioned at the vertices of a regular two-dimensional lattice. Abnormal cells divide k times as fast as normal cells. Whenever a cell divides, the daughter is the same type as the parent and replaces an adjacent cell. The Kolmogorov forwards and backwards equations are derived, and then used to obtain bounds for the distribution function of the time when all the abnormal cells are forced from the plane. These bounds are used to comment on the non-asymptotic variance of the number of abnormal cells at a given time and on a method of estimating k.