Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-14T07:09:37.207Z Has data issue: false hasContentIssue false

Some aspects of the non-asymptotic behaviour of a two-dimensional invasion process

Published online by Cambridge University Press:  14 July 2016

D. Y. Downham*
Affiliation:
University of Liverpool
S. B. Fotopoulos*
Affiliation:
University of Liverpool
*
Postal address: Department of Computational and Statistical Science, University of Liverpool, Victoria Building, Brownlow Hill, P.O. Box 147, Liverpool L69 3BX, U.K.
Postal address: Department of Computational and Statistical Science, University of Liverpool, Victoria Building, Brownlow Hill, P.O. Box 147, Liverpool L69 3BX, U.K.

Abstract

Normal and abnormal cells are positioned at the vertices of a regular two-dimensional lattice. Abnormal cells divide k times as fast as normal cells. Whenever a cell divides, the daughter is the same type as the parent and replaces an adjacent cell. The Kolmogorov forwards and backwards equations are derived, and then used to obtain bounds for the distribution function of the time when all the abnormal cells are forced from the plane. These bounds are used to comment on the non-asymptotic variance of the number of abnormal cells at a given time and on a method of estimating k.

Type
Short Communications
Copyright
Copyright © Applied Probability Trust 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Downham, D. Y. and Morgan, R. K. B. (1973a) Growth of abnormal cells. Nature (London) 242, 528530.CrossRefGoogle ScholarPubMed
Downham, D. Y. and Morgan, R. K. B. (1973b) A stochastic model for a two-dimensional growth on a square lattice. Bull. Inst. Internat. Statist. 45, 324329.Google Scholar
Feller, W. (1970) An Introduction to Probability Theory and its Applications, Vol. I, 3rd edn. Wiley, New York.Google Scholar
Kelly, F. P. (1977) The asymptotic behaviour of an invasion process. J. Appl. Prob. 14, 584590.CrossRefGoogle Scholar
Mollison, D. (1972) Conjecture on the spread of infection in two-dimensions disproved. Nature (London) 240, 467468.Google Scholar
Williams, T. and Bjerknes, R. (1972) Stochastic model for abnormal clone spread through epithelial basal layer. Nature (London) 236, 1921.Google Scholar