In this work, simple, low profile, compact quarter-mode substrate-integrated waveguide (QMSIW)-based antennas are proposed for Wireless Local Area Network (WLAN) at 5.2/5.5 GHz and Wireless Body Area Network (WBAN) at 5.8 GHz, respectively. By implementing QMSIW technique, the electrical size of the antenna is reduced up to 1/4th of the conventional circular SIW cavities. Thanks to the quarter mode concept, the antenna size is reduced significantly by preserving its dominant mode. The resonant frequency of the dominant mode TM010 is independently tuned at 5.2, 5.5, and 5.8 GHz after loading the QMSIW cavity with metalized via holes, subsequently. The on-body performance of the antenna is verified on pork tissues at 5.8 GHz and it is found to be insensitive with respect to surroundings. The measured gain and simulated efficiency of the proposed antenna at 5.8 GHz in free space are 4.8 dBi and 92%, while in the proximity of pork tissues values are 3.25 dBi and 57%, respectively. Moreover, the measurement results demonstrate a good matching with the simulation results.